2015년 국내에서 분리된 살모넬라의 혈청형 및 항균제 감수성 = Serotyping and Antimicrobial Susceptibility of Salmonella Isolated in Korea in 2015

다국어 초록 (Multilingual Abstract)

Background: Salmonella is an important pathogen that causes gastroenteritis and sepsis in humans.
Recently, changes in serotype prevalence and an increase in antimicrobial resistance have been reported. This study investigated the distribution of Salmonella serotypes and determined the antimicrobial susceptibility of various strains.
Methods: We collected 113 Salmonella isolates other than Salmonella serotype Typhi from 18 university hospitals in 2015. The serotypes were identified by Salmonella antisera O and H according to the Kauffman White scheme. Antimicrobial susceptibility tests for 12 antibiotics were performed using the disk diffusion method or E-test.
Results: We identified 22 serotypes. Serotype group B (44.2%) was the most common, followed by groups C (34.5%) and D (21.2%). Salmonella I 4,[5],12:i:- (23.0%), S. Enteritidis (16.8%), and S. Typhimurium (12.4%) were the most common species. Resistance rates for ampicillin, chloramphenicol, ceftriaxone, and trimethoprim/sulfamethoxazole were 46.9%, 18.5%, 8.8%, and 5.3%, respectively. The intermediate resistance rate to ciprofloxacin was 29.2%. Six isolates were extended-spectrum β-lactamase (ESBL) producers, including 5 blaCTX-M-15 and 1 blaCTX-M-55.
Conclusion: There have been changes in the serotype prevalence and antimicrobial resistance of Salmonella in Korea, with a high prevalence of CTX-M 15-positive strains. Continuous monitoring of Salmonella serotypes and antimicrobial resistance is warranted. (Ann Clin Microbiol 2019;22:55-60)

참고문헌 (Reference)

• 1 황경화, "인천지역 설사환자에서 분리한 Salmonella enterica serovar Enteritidis의 항생제 내성 및 다제내성 양상" 한국미생물학회 45 (45): 99-104, 2009
• 2 김석호, "사람에서 분리된 살모넬라의 국내 유행 혈청형과 해외 유입 혈청형, 2004~2005" 대한미생물학회 36 (36): 69-72, 2006
• 3 권오근, "경북지역 설사환자에서 분리된 Salmonella 균의 특성 분석" 대한임상미생물학회 17 (17): 50-57, 2014
• 4 Lee HJ, "Serovars and antimicrobial susceptibility of the recent clinical isolates of Salmonella" 15 : 422-429, 1995
• 5 Lee JY, "Serotyping and antimicrobial susceptibility of Salmonella spp.:nationwide multicenter study in Korea" 66 : 284-289, 2013
• 6 Lee HJ, "Salmonellosis" 4 : 5-10, 2001
• 7 Arlet G, "Salmonella resistant to extended-spectrum cephalosporins : prevalence and epidemiology" 8 : 1945-1954, 2006
• 8 이덕용, "Salmonella I 4,[5],12:i:-의 국내 발생 사례 및 분리주의 특성 분석" 대한감염학회 43 (43): 186-190, 2011
• 9 Yun YS, "Prevalence and characteristics of Salmonella spp. isolated in Korea, 2015" 9 : 174-180, 2016
• 10 Yun YS, "Prevalence and characteristics of Salmonella spp. in Korea, 2014" 8 : 470-476, 2015
• 11 Park HM, "Prevalence and characteristics of Salmonella spp. in Korea, 2011" 5 : 461-466, 2012
• 12 CLSI, "Performance standards for antimicrobial susceptibility testing; twenty-fifth informational supplement. CLSI document M100-S25"
• 13 Mead PS, "Food-related illness and death in the United States" 5 : 607-625, 1999
• 14 Miriagou V, "Expandedspectrum cephalosporin resistance in non-typhoid Salmonella" 23 : 547-555, 2004
• 15 이건희, "Case Report of Pediatric Gastroenteritis Due to CTX-M-15 Extended-Spectrum β-Lactamase-Producing Salmonella enterica Serotype Enteritidis" 대한진단검사의학회 29 (29): 461-464, 2009
• 16 정혜선, "2006-2008년 국내 임상검체 및 동물에서 분리된 Non-Typhoidal Salmonella 균주에서의 Extended-Spectrum β-Lactamase, Plasmid-Mediated AmpC β-Lactamase와 Plasmid-Mediated Quinolone 내성 qnr 유전자의 빈도" 대한임상미생물학회 15 (15): 14-20, 2012