Sphingosine Kinase: Biochemical and CellularRegulation and Role in Disease

참고문헌 (Reference)

• 1 Wu, W, "VEGF receptor expression and signaling in human bladder tumors" 22 : 3361-3370, 2003
• 2 Igarashi, J, "VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors" 100 : 2003
• 3 Xia, P, "Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway" 95 : 1998
• 4 Taha, T. A, "Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism" 280 : 2005
• 5 Katsuma, S, "Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation" 300 : 577-584, 2003
• 6 Jolly, P. S, "Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis" 199 : 959-970, 2004
• 7 Tanimoto, T, "Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS)" 277 : 2002
• 8 Rosenfeldt, H. M, "The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility" 29 : 836-839, 2001
• 9 Kono, M, "The sphingosine-1- phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis" 279 : 2004
• 10 Pettus, B. J, "The sphingosine kinase 1/sphingosine-1- phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha" 17 : 1411-1421, 2003
• 11 Baumruker, T, "The role of sphingosine and ceramide kinases in inflammatory responses" 96 : 175-185, 2005
• 12 Pitson, S. M, "The nucleotidebinding site of human sphingosine kinase 1" 277 : 2002
• 13 Stahelin, R. V, "The mechanism of membrane targeting of human sphingosine kinase 1" 280 : 2005
• 14 Kaneider, N. C, "The immune modulator FTY720 targets sphingosinekinase- dependent migration of human monocytes in response to amyloid beta-protein and its precursor" 18 : 1309-1311, 2004
• 15 Mao, C, "The dihydrosphingosine- 1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses" 342 : 667-675, 1999
• 16 Nagiec, M. M, "The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases" 273 : 1998
• 17 Pettus, B. J, "The coordination of prostaglandin E2 production by sphingosine-1- phosphate and ceramide-1-phosphate" 68 : 330-335, 2005
• 18 Nofer, J. R, "Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids" 276 : 2001
• 19 Cuvillier, O, "Suppression of ceramidemediated programmed cell death by sphingosine-1-phosphate" 381 : 800-803, 1996
• 20 Gijsbers, S, "Subcellular study of s phingoid base phosphorylation in rat tissues: evidence for multiple sphingosine kinases" 1532 : 37-50, 2001
• 21 Yu, H, "Structural basis for the binding of proline-rich peptides to SH3 domains" 76 : 933-945, 1994
• 22 Kleuser, B, "Stimulation of nuclear sphingosine kinase activity by plateletderived growth factor" 503 : 85-90, 2001
• 23 Alemany, R, "Stimulation of sphingosine-1-phosphate formation by the P2Y(2) receptor in HL-60 cells: Ca(2+) requirement and implication in receptormediated Ca(2+) mobilization, but not MAP kinase activation" 58 : 491-497, 2000
• 24 Krump-Konvalinkova, V, "Stable knock-down of the sphingosine 1- phosphate receptor S1P1 influences multiple functions of human endothelial cells" 25 : 546-552, 2005
• 25 Spiegel, S, "Sphingosine-1-phosphate: an enigmatic signalling lipid" 4 : 397-407, 2003
• 26 Yatomi, Y, "Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets" 86 : 193-202, 1995
• 27 Zhang, H, "Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation" 114 : 155-167, 1991
• 28 Wang, F, "Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors" 59 : 6185-6191, 1999
• 29 Olivera, A, "Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens" 365 : 557-560, 1993
• 30 Xie, J. H, "Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells" 170 : 3662-3670, 2003
• 31 Argraves, K. M, "Sphingosine-1- phosphate signaling promotes critical migratory events in vasculogenesis" 279 : 2004
• 32 Hong, G, "Sphingosine-1- phosphate modulates growth and adhesion of ovarian cancer cells" 460 : 513-518, 1999
• 33 Xu, C. B, "Sphingosine signaling and atherogenesis" 25 : 849-854, 2004
• 34 Olivera, A, "Sphingosine kinase: a mediator of vital cellular functions" 64 : 123-134, 2001
• 35 van Koppen, C. J, "Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors" 68 : 2535-2540, 2001
• 36 Meyer zu Heringdorf, D, "Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors" 17 : 2830-2837, 1998
• 37 Limaye, V. S, "Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members" 105 : 3169-3177, 2005
• 38 Chen, X. L, "Sphingosine kinase- 1 mediates TNF-alpha-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow" 287 : 1452-1458, 2004
• 39 Maceyka, M, "Sphingosine kinase, sphingosine-1-phosphate, and apoptosis" 1585 : 193-201, 2002
• 40 Liu, H, "Sphingosine kinase type 2 is a putative BH3-Only protein that induces apoptosis" 2003
• 41 Nava, V. E, "Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells" 281 : 115-127, 2002
• 42 Sukocheva, O. A, "Sphingosine kinase transmits estrogen signaling in human breast cancer cells" 17 : 2002-2012, 2003
• 43 Shu, X, "Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases" 22 : 7758-7768, 2002
• 44 Machwate, M, "Sphingosine kinase mediates cyclic AMP suppression of apoptosis in rat periosteal cells" 54 : 70-77, 1998
• 45 Xia, P, "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling" 277 : 7996-8003, 2002
• 46 Bektas, M, "Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression" 24 : 178-187, 2005
• 47 Igarashi, N, "Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis" 278 : 2003
• 48 Kawamori, T, "Sphingosine kinase 1 is upregulated in colon carcinogenesis" 20 : 386-388, 2006
• 49 Delon, C, "Sphingosine kinase 1 is an intracellular effector of phosphatidic acid" 279 : 2004
• 50 Yamanaka, M, "Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation" 279 : 2004
• 51 Thompson, C. R, "Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: Inhibition of SK1 translocation by mycobacterium tuberculosis" 174 : 3551-3561, 2005
• 52 Min, J, "Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin" 4 : 178-189, 2005
• 53 Olivera, A, "Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival" 147 : 545-558, 1999
• 54 Nava, V. E, "Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells" 60 : 4468-4474, 2000
• 55 Spiegel, S, "Sphingosine 1-phosphate: a prototype of a new class of second messengers" 65 : 341-344, 1999
• 56 Van Brocklyn, J. R, "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G proteincoupled receptor H218" 274 : 4626-4632, 1999
• 57 Kimura, T, "Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3" 348 : 71-76, 2000
• 58 Garcia, J. G, "Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement" 108 : 689-701, 2001
• 59 Yatomi, Y, "Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid" 272 : 5291-5297, 1997
• 60 Yang, L, "Sphingosine 1-phosphate formation and intracellular Ca2+ mobilization in human platelets: evaluation with sphingosine kinase inhibitors" 126 : 84-89, 1999
• 61 Igarashi, J, "Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways" 276 : 2001
• 62 Matsushita, K, "Sphingosine 1-phosphate activates Weibel-Palade body exocytosis" 101 : 2004
• 63 Sanna, M. G, "Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate" 279 : 2004
• 64 Paik, J. H, "Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization" 18 : 2392-2403, 2004
• 65 Yatomi, Y, "Sphingosine 1- phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum" 121 : 969-973, 1997
• 66 English, D, "Sphingosine 1- phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis" 14 : 2255-2265, 2000
• 67 Cinamon, G, "Sphingosine 1- phosphate receptor 1 promotes B cell localization in the splenic marginal zone" 5 : 713-720, 2004
• 68 Kimura, T, "Sphingosine 1- phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells" 276 : 2001
• 69 Lee, O. H, "Sphingosine 1- phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells" 264 : 743-750, 1999
• 70 Olivera, A, "Sphingosine kinase type 1 Induces G12/13-mediated stress fiber formation yet promotes growth and survival independent of G protein coupled receptors" 278 : 2003
• 71 Wu, W, "Sphingosine kinase protects lipopolysaccharide-activated macrophages from apoptosis" 24 : 7359-7369, 2004
• 72 Stoffel, W, "Sphingosine kinase in blood platelets" 354 : 562-566, 1973
• 73 Jin, Z. Q, "Sphingosine kinase activation mediates ischemic preconditioning in murine heart" 110 : 1980-1989, 2004
• 74 Coursol, S, "Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins" 423 : 651-654, 2003
• 75 Louie, D. D, "Sphingolipid base metabolism. Partial purification and properties of sphinganine kinase of brain" 251 : 4557-4564, 1976
• 76 Katsuma, S, "Signalling mechanisms in sphingosine 1-phosphatepromoted mesangial cell proliferation" 7 : 1217-1230, 2002
• 77 Rhoads, A. R, "Sequence motifs for calmodulin recognition" 11 : 331-340, 1997
• 78 Hobson, J. P, "Role of the sphingosine-1-phosphate receptor EDG-1 in PDGFinduced cell motility" 291 : 1800-1803, 2001
• 79 Auge, N, "Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase" 274 : 1999
• 80 Meyer zu Heringdorf, D, "Role of sphingosine kinase in Ca(2+) signalling by epidermal growth factor receptor" 461 : 217-222, 1999
• 81 Schaphorst, K. L, "Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products" 285 : 258-267, 2003
• 82 Miura, Y, "Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets" 127 : 909-914, 2000
• 83 Chae, S. S, "Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference" 114 : 1082-1089, 2004
• 84 Mazurek, N, "Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response--a preliminary note" 198 : 1-9, 1994
• 85 Nakade, Y, "Regulation of sphingosine kinase 1 gene expression by protein kinase C in a human leukemia cell line, MEG-O1" 1635 : 104-116, 2003
• 86 Olivera, A, "Purification and characterization of rat kidney sphingosine kinase" 273 : 1998
• 87 Khan, W. A, "Protein kinase C and platelet inhibition by D-erythrosphingosine: comparison with N,N-dimethylsphingosine and commercial preparation" 172 : 683-691, 1990
• 88 Buehrer, B. M, "Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity" 1303 : 233-242, 1996
• 89 Peng, X, "Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury" 169 : 1245-1251, 2004
• 90 Stoffel, W, "Properties and specificities of sphingosine kinase from blood platelets" 354 : 1311-1316, 1973
• 91 Deutschman, D. H, "Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate" 146 : 62-68, 2003
• 92 Olivera, A, "Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma" 13 : 1593-1600, 1999
• 93 Hla, T, "Physiological and pathological actions of sphingosine 1-phosphate" 15 : 513-520, 2004
• 94 Meyer zu Heringdorf, D, "Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors" 554 : 443-449, 2003
• 95 Pitson, S. M, "Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling" 201 : 49-54, 2005
• 96 Billich, A, "Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases" 278 : 2003
• 97 Sanchez, T, "Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability" 278 : 2003
• 98 Cummings, R. J, "Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells" 277 : 2002
• 99 Johnson, K. R, "PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)" 277 : 2002
• 100 Yatomi, Y, "N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets" 35 : 626-633, 1996
• 101 Liu, H, "Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform" 275 : 2000
• 102 Kohama, T, "Molecular cloning and functional characterization of murine sphingosine kinase" 273 : 1998
• 103 Allende, M. L, "Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720" 279 : 2004
• 104 Hla, T, "Lysophospholipids--receptor revelations" 294 : 1875-1878, 2001
• 105 Fukushima, N, "Lysophospholipid receptors" 41 : 507-534, 2001
• 106 Meyer Zu Heringdorf, D, "Lysophospholipid receptordependent and -independent calcium signaling" 92 : 937-948, 2004
• 107 Matloubian, M, "Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1" 427 : 355-360, 2004
• 108 Park, Y. S, "Liposomal N,N,N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signaling as a target in cancer therapy III" 54 : 2213-2217, 1994
• 109 Hait, N. C, "Lcb4p sphingoid base kinase localizes to the Golgi and late endosomes" 532 : 97-102, 2002
• 110 Funato, K, "Lcb4p is a key regulator of ceramide synthesis from exogenous long chain sphingoid base in Saccharomyces cerevisiae" 278 : 7325-7334, 2003
• 111 Edsall, L. C, "Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation" 17 : 6952-6960, 1997
• 112 Rikitake, Y, "Involvemen of endothelial nitric oxide in sphingosine-1-phosphate-induced angiogenesis" 22 : 108-114, 2002
• 113 Buehrer, B. M, "Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways" 267 : 3154-3159, 1992
• 114 Licht, T, "Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3)" 102 : 2099-2107, 2003
• 115 Yagi, H, "Immunosuppressant FTY720 inhibits thymocyte emigration" 30 : 1435-1444, 2000
• 116 Tolle, M, "Immunomodulator FTY720 induces eNOSdependent arterial vasodilatation via the lysophospholipid receptor S1P3" 96 : 913-920, 2005
• 117 Forrest, M, "Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes" 309 : 758-768, 2004
• 118 Inagaki, Y, "Identification of functional nuclear export sequences in human sphingosine kinase 1" 311 : 168-173, 2003
• 119 Ren, R, "Identification of a ten-amino acid proline-rich SH3 binding site" 259 : 1157-1161, 1993
• 120 Fukuda, Y, "Identification of PECAM-1 association with sphingosine kinase 1 and its regulation by agonist-induced phosphorylation" 1636 : 12-21, 2004
• 121 Hayashi, S, "Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein" 277 : 2002
• 122 Pitson, S. M, "Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes" 350 : 429-441, 2000
• 123 Melendez, A. J, "Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution" 251 : 19-26, 2000
• 124 Roviezzo, F, "Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1- phosphate" 101 : 2004
• 125 Kimura, T, "Highdensity lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors" 23 : 1283-1288, 2003
• 126 Xia, P, "High density lipoproteins (HDL) interrupt the sphingosine kinase signaling pathway. A possible mechanism for protection against atherosclerosis by HDL" 274 : 1999
• 127 Nofer, J. R, "HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3" 113 : 569-581, 2004
• 128 Geoffroy, K, "Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels" 579 : 1249-1254, 2005
• 129 Nava, V. E, "Functional characterization of human sphingosine kinase-1" 473 : 81-84, 2000
• 130 Melendez, A, "FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking" 273 : 9393-9402, 1998
• 131 Brinkmann, V., "FTY720: targeting Gprotein coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity" 14 : 569-575, 2002
• 132 Brinkmann, V, "FTY720: altered lymphocyte traffic results in allograft protection" 72 : 764-769, 2001
• 133 Brinkmann, V, "FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation" 21 : 49-52, 2000
• 134 Brinkmann, V, "FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function" 4 : 1019-1025, 2004
• 135 Yopp, A. C, "FTY720-enhanced T cell homing is dependent on CCR2, CCR5, CCR7, and CXCR4: evidence for distinct chemokine compartments" 173 : 855-865, 2004
• 136 Chen, S, "FTY720, a novel transplantation drug, modulates lymphocyte migratory responses to chemokines" 33 : 3057-3063, 2001
• 137 Chiba, K, "FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing" 160 : 5037-5044, 1998
• 138 Honig, S. M, "FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes" 111 : 627-637, 2003
• 139 Brinkmann, V, "FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression" 33 : 530-531, 2001
• 140 Pinschewer, D. D, "FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory" 164 : 5761-5770, 2000
• 141 Ancellin, N, "Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1- phosphate generation and the induction of angiogenic vascular maturation" 277 : 6667-6675, 2002
• 142 Pitson, S. M, "Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase" 275 : 2000
• 143 Jolly, P. S, "Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors" 105 : 4736-4742, 2005
• 144 Banno, Y, "Evidence for the presence of multiple forms of Sph kinase in human platelets" 335 : 301-304, 1998
• 145 Hannun, Y. A, "Enzymes of sphingolipid metabolism: from modular to integrative signaling" 40 : 4893-4903, 2001
• 146 Hirschberg, C. B, "Enzymatic formation of dihydrosphingosine l-phosphate" 245 : 3084-3090, 1970
• 147 Blom, T, "Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response" 17 : 827-836, 2005
• 148 Feistritzer, C, "Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation" 105 : 3178-3184, 2004
• 149 Rosen, H, "Egress: a receptorregulated step in lymphocyte trafficking" 195 : 160-177, 2003
• 150 Olivera, A, "Effect of acidic phospholipids on sphingosine kinase" 60 : 529-537, 1996
• 151 Safadi-Chamberlain, F, "Effect of a membrane-targeted sphingosine kinase 1 on cell proliferation and survival" 388 : 827-834, 2005
• 152 Young, K. W, "Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells" 402 : 55-59, 2000
• 153 Liu, Y, "Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation" 106 : 951-961, 2000
• 154 Urtz, N, "Early activation of sphingosine kinase in mast cells and recruitment to FcepsilonRI are mediated by its interaction with Lyn kinase" 24 : 8765-8777, 2004
• 155 Van Brocklyn, J. R, "Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival" 142 : 229-240, 1998
• 156 Ng, C. K, "Drought-induced guard cell signal transduction involves sphingosine-1-phosphate" 410 : 596-599, 2001
• 157 Taha, T. A, "Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53" 279 : 2004
• 158 Fukuda, Y, "Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1" 309 : 155-160, 2003
• 159 Chin, T.-Y, "Distinct effects of different calcium-mobilizing agents on cell death in NG108-15 neuroblastoma X glioma cells" 61 : 486-494, 2002
• 160 French, K. J, "Discovery and evaluation of inhibitors of human sphingosine kinase" 63 : 5962-5969, 2003
• 161 Toman, R. E, "Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension" 166 : 381-392, 2004
• 162 Melendez, A. J, "Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells" 277 : 2002
• 163 Xu, C. B, "Derythro N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells" 164 : 237-243, 2002
• 164 Alemany, R, "Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate" 509 : 239-244, 2001
• 165 Malik, Z. A, "Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase" 170 : 2811-2815, 2003
• 166 Lacana, E, "Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity" 277 : 2002
• 167 Herr, D. R, "Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function" 279 : 2004
• 168 Nishiura, H, "Characterization of sphingolipid long-chain base kinase in Arabidopsis thaliana" 28 : 747-748, 2000
• 169 Lanterman, M. M, "Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants" 332 : 525-531, 1998
• 170 Sugiura, M, "Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization" 277 : 2002
• 171 Endo, K, "Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice" 51 : 1613-1618, 1991
• 172 Okoshi, H, "Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,Ntrimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation" 51 : 6019-6024, 1991
• 173 Jin, Z. Q, "Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts" 282 : 1970-1977, 2002
• 174 Choi, O. H, "Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor" 380 : 634-636, 1996
• 175 Young, K. W, "Ca(2+)/ calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation" 33 : 119-128, 2003
• 176 Henning, G, "CC chemokine receptor 7-dependent and -independent pathways for lymphocyte homing: modulation by FTY720" 194 : 1875-1881, 2001
• 177 Lee, C, "Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition" 57 : 955-960, 2004
• 178 Yokota, S, "Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition" 578 : 106-110, 2004
• 179 Gennero, I, "Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1- phosphate hydrolysis on mesangial cells cultured at low cell density" 277 : 2002
• 180 Melendez, A. J, "Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis" 173 : 1596-1603, 2004
• 181 Ibrahim, F. B, "Anaphylatoxin signaling in human neutrophils. A key role for sphingosine kinase" 279 : 2004
• 182 Xia, P, "An oncogenic role of sphingosine kinase" 10 : 1527-1530, 2000
• 183 Maceyka, M, "Aminoacylase 1 is a sphingosine kinase 1-interacting protein" 568 : 30-34, 2004
• 184 Mandala, S, "Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists" 296 : 346-349, 2002
• 185 Lee, M. J, "Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis" 8 : 693-704, 2001
• 186 Graeler, M, "Activation-regulated expression and chemotactic function of sphingosine 1- phosphate receptors in mouse splenic T cells" 16 : 1874-1878, 2002
• 187 Xia, P, "Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells" 274 : 1999
• 188 Rius, R. A, "Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors" 417 : 173-176, 1997
• 189 Pitson, S. M, "Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation" 22 : 5491-5500, 2003
• 190 Smith, R. E, "A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes" 102 : 2532-2540, 2003
• 191 Melendez, A, "A molecular switch changes the signalling pathway used by the Fc gamma RI antibody receptor to mobilise calcium" 8 : 210-221, 1998
• 192 Kleuser, B, "1Alpha,25- dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase" 58 : 1817-1824, 1998