항균제 내성 대장균의 생태적 분포 Ⅰ. : Ampicillin, mecillinam, cefoperazone과 lactamoxef에 관하여 = Ecology of E. coli Strains Resistant to Ampicillin, Mecillinam, Cefoperazone and Lactomoxef in Korea

다국어 초록 (Multilingual Abstract)

We studied the differences in the MIC distribution of E. coli isolates from a doctorlezs-remote area (Kwang Won Do province=KWD), a leprosarium (So Rock Go island=SRDj, and Seoul Iiational University Hospita: (SKUH) against amFiciliin mecilliaam, cefoperazcne and lactamoxef.
So the widespread and prolonged use of antimicrobial agents is presumed to facilitate the increase of drug-resistant strains among the normal flora of the residents in a cornmunit? that the isolates from SNUH m-ere further divided into two groups, SNUH in-patient (I?] and SKUH out-patient (OP) and 'the isolates from SRD into DCS (isolates from leprcsy patients who are taking DDS only) and Rf (isolates from leprosy patients who are taking rifampicin and DGS) groups.
Number of E. coEi isolates studied were 33 strains from SNUR patients (SNUH-OP, 47), 150 strains from SRD patients (SRC-DCS, 102; SRD Rf, 4P), a i d 120 strains from KWD residents..
Distribution of E. coli strains according to their respective MICs shons that E. coii po-ssessex not oniy an intrinsic component in resistance (or susceptibility) to the drugs (azi-picillin, 1--8,ug/ml: meciilinam, @.12S--l,ug/m!; cefoperazone, 0. GGy0.-.5pgjml; lactanoxo,f, 0.06-Q.5pgjml) but also a distinct MIC value of acquired resistance quite Cifiei-ent fion: the intrinsic one in the case of ampicillin (2250pg/'ml).
The facts t h a t the carriage rate of ampicillin resistant strains in.the hospital patiezts x\as the highest alliong the study groups and more specifically that those of the out patient as not less than those of the in-patient and that those of residents of doctorless-remote area va3 the least suggest that ampicillin resistarce in Korea is a localized problem in some community rather than a nation-wide one.
That the MIC distributions of the resistant strains to mecillinam ard/or cefoperaxore were quite different from those of ampicillin is consistent not only with the fact that me- cillinam and cef operazone are less beta lactamase-stable than lactamoxef is. but also suggest5 that there is more than one kind of relevant beta-lactamase in Korean E. coZi strains.