전립선비대증과 전립선암의 감별진단에서 혈청 PSAD 에 관한 연구 = The Study of Serum PSAD in Differential Diagnosis of BPH and Prostate Carcinoma

국문 초록 (Abstract)

전립선 특이항원(Prostate Specific Antigen)은 전립선암의 암 표식자로서 매우 유용한 혈청 지표이지만 민감도와 특이도가 낮기 때문에 전립선암을 진단하는 데에는 그 유용성이 제한되어 있다. 이러한 문제점을 보완하기 위하여, 저자는 전립선 특이항원치와 전립선 용적의 비로 정의되는 전립선 특이항원 밀도(Prostate Specific Antigen Density)를 계산하여 그 유용성을 검토하였는데, 전립선 특이항원치가 4.1ng/ml에서 20.0ng/ml 사이인 환자군에서는 전립선 비대증과 전립선암을 감별하는데 있어서 전립선 특이항원 밀도가 유용한 것으로 관찰되었다.

다국어 초록 (Multilingual Abstract)

Prostate specific antigen (PSA) is an extremely valuable tumor marker of prostate carcinoma. However, its use in detection of prostate cancer is limited by low sensitivity and specificity. To enhance the accuracy of serum PSA, I. used the quotient of serum PSA and prostate volume, which was referred to as prostrate specific antigen density(PSAD). Prostrate volume in this study was calculated from transrectal ultrasonographic determination (volume = 0.52 x length x width x depth). The serum PSA was analyzed using the Hybritech Tandem-R assay. Prostate biopsies were performed transrectally from at least six sites.
The cancer detection rate was 2.2% (1 out of 45 patients) in the group wish PSA value of less than 4.0ng/ml and 8.1% (3 out of 37 patients) in the group with PSA value of 4.1 to 10.0ng/ml. In the latter group, mean PSA values for the positive(n=3) and negative(n=34) biopsy groups were 7.10±1.22 and 6.61±1.79ng/ml respectively(p=0.4630), but mean PSAD values were 0.275±0.089 and 0.187±0.078 respectively(p = 0.0045). In the group of 14 patients with PSA value of 10.1 to 20.0ng/ml, the cancer detection rate was 28.5% (4 out of 14 patients) and the mean PSA values for the positive(n=4) and negative(n=10) biopsy groups were 15.5±3.09 and 13.4±2.78ng/ml respectively(p=0.1038), but mean PSAD values were 0.535±0.082 and 0.334±0.182 respectively(p = 0.0128).
These results suggest that PSAD is useful in distinguishing BPH and prostate cancer in the patients with intermediate PSA values (4.1ng/ml to 20.0ng/ml).

목차 (Table of Contents)

• Ⅰ.서론
• Ⅱ.연구 대상 및 방법
• 1.연구 대상
• 2.연구 방법
• Ⅲ.결과
• Ⅳ.고찰
• Ⅴ.결론