Alloxan 投與家兎에 對한 同種皮膚利殖實驗 = STUDIES ON THE SURVIVAL OF SKIN HOMOGRAFTS IN RABBITS TREATED WITH ALLOXAN
저자
柳在德 (延世大學校 醫科大學 藥理學敎室, 外科學敎室)
발행기관
학술지명
권호사항
발행연도
1941
작성언어
Korean
KDC
510
자료형태
학술저널
수록면
73-86(14쪽)
It is no exaggeration to say that surgery would enter into a new dimension of accomplishment if tissues or organs could be transplanted with the same freedom between two different individuals as between one part and another of a same individual.
The homotransplantation of skin is certainly one of the unsolved problems in medicine and numerous studies for this problem have been designed, conducted and reported. Among all varied, homografts, the skin has become the primary choice for investigation by more researchers because of its ease in operation and observation.
The present situation is that the all skin homografts in any part of the body must be presumed to be impermanent. However, clinically only two types of skin transplantations have been successful: skin homografts between monozygotic twins (Padgett, 1932; Brown, 1937; Schattner, 1944; Converse and Duchet, 1947; McIndoe and Franceschetti, 1950; Blandford and Garcia, 1953; Cox and Fredricks, 1956), and skin homografts upon recipients with agammaglobulinemia (Good and Varco, 1955; Varco et al., 1955;
Good et al., 1957).
When the skin is transplanted as a homograft from one individual to another, th2e circulatory re-establishment of the homograft take place and its vessels become filled with blood from the host in 4 days after the transplantation. The blood is seen to circulate freely in the graft; the gross and microscopic appearance of the homograft is comparable to that of an autograft (Medawar, 1944, 1945; Edgerton et al., 1957; Converse and Rapaport, 1956). After a period of a little more than a week, however, the flow of blood in the vessels of the homograft ceases, the vessels become thrombosed, vascular permeability increases, the vessel walls become ruptured, the erythrocytes become extravasated into the perivascular tissue spaces of the graft, and finally the graft become necrotic and is rejected by the host (Scothorne and McGregor, 1953; Ohmori and Kurata, 1960). In this known rejection phenomenon of the homograft a time factor seems to play a role. A lapse of about 7 days usually occurs before the evidences of rejection such as vascular thromboses and necrosis occur. This 7 day period is comparable to the average time period during which the body builds up an effective antibody level against a foreign antigen.
The "second-set phenomenon" (Medawar, 1944) seems to be another factor? in the immunological reaction. A second-set of skin homografts taken from the same donor and transplanted to the same host sloughs more rapidly than the first-set of homografts (Gibson and Medawar, 1943; Medawar, 1944, 1945, 1946; Woodruff and Simpson, 1955; Allg?wer et al., 1952; Lehrfeld et al., 1955; Rapaport and Converse, 1958). The shorter survival of second-set grafts maybe attributed to an acquired immunity reaction previously developed in the host against the first-set of grafts.
Research prior to and subsequent to Medawar's basic studies tends to confirm his acquired immunity hypothesis. Clarification of the nature of this immunological react ion is one of the primary goals of homotransplantation research. Prolonged or permanent survival of tissue homografts may be possible if this reaction can be prevented, altered, paralyzed or depressed by one or more methods.
Cannon (1957) has shown that approximately 5 to 10% of skin homografts taken, from one-day-old chickens and transplanted to one-day-old chickens are permanently successful. The report of Peer et al. (1957) supports the findings of Cannon in that it suggests that neonatal or even young infant tissue apparently lacks the absolute specific antigenicity characteristic of adult tissues. Billingham et al. (1955), Woodruff and Simpson (1955) have induced tolerance by the injection of cells from the prospective adult donor into newborn animals soon after birth, and found a prolonged or permanent survival of the skin homografts transplanted from the original donor when the animals had reached maturity. Hardin and Werder (1954, 1955), Piomelli et al. (1961), using total body irradiation in young mice and rabbit, observed a prolongation of skin homo graft survival for 2 to 7 weeks, as did Conway et al. (1955) who irradiated only the recipient site. Levinson and Nechels (1956) obtained a markedly prolonged survival of
skin homografts in rats treated with nitrogen mustard. Stark et al. (1960) and Snyder (1964) observed a doubled period of survival of skin homografts in rabbits following regional lymphadenectomy and splenectomy. Billingham et al. (1951) and Woodruff and Llaurado (1956) have reported that adrenocortical hormones, administered either systemically or locally, brought about a significant prolongation of homograft survival in rabbits. Calnan and Kulatilake (1962), Ballantyne et al. (1962, 1963) and Converse et al. (1963) have observed a 2 to 3 times longer survival over the control in massive skin homografts in rats. Snyderman et al. (1960) and Gardner et al. (1961, 1962) have experienced a prolonged survival of skin homografts in the advanced state of various malignant tumor patients, and the chemotherapeutic agents for carcinoma, such as nitrogen mustard, 6-mercaptopurine, cyclophosphomide, 5-flourouracil, methotrexate, thioguanine and azoserine have been proved effective in prolonging the survival of skin homografts in animals by Levinson and Necheles (1956), McLaren (1961) and Sutton et al. (1991, 1963) . Schatten et al. (1958) reported 10.5 days survival (control 7.1 days) of skin homografts in hypophysectomized and hypothyroid rats and stated that hypometabolism of the host cell may result in a less intense antibody response. Heslop et al. (1954) have showed 50 to 100% longer survival of skin homografts than that of control in pregnant rabbits, and Dammin et al. (1957) in uremic patients, and Smidly et al. (1960) in uremic rabbits, have showed a significant prolongation of survival of the skin homografts. Besides the above mentioned, the skin homografts in animal experiments treated with antihistaminics (Forster and Hanrahan, 1948; Conway et al., 1954), anticoagulants (Conway et al., 1953), sodium salicylate (Conway et al., 1955), and RNA (Ashley et al., 1960) have shown also a significant prolongation of their survival.
In light of above review of accumulated knowledge of the problem of homotransplantation of skin, an investigation of the effect of hyperglycemia was undertaken, in order to clarify a clinical impression of a prolongation of survival time of skin homografts on a severely burned diabetic patient.
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