Ouabain의 LD_(50)에 미치는 Manganese Chloride의 影響 = The Influence of Manganese Chloride to the LD_(50) of Ouabain

다국어 초록 (Multilingual Abstract)

The LD_(50) of Ouabain to the frog (Rana nigromaculata) and mice in Korea are jstudied. And also the effects of manganese chloride to the LD_(50) of Ouabain are observedfas follows.
1. LD_(50) of Ouabain to the mice is 14.50mg/kg by Behrens Kaeber (B.K.) method and 13,55mg/kg by Van Der Waerden (V.D.W.) method.
2. LD_(50) of Quabain to the mice, premedicated with manganese chloride 60mg/kg, is 12,80mg/kg by B.K. method and 11.72mg 1 kg by V.D.W. method.
3. LD_(50) of Ouabain to the frog is 0.17mg/kg by B.K. method and 0.17mg/kg by V.D.W. method.
4. LD_(50) of Ouabain to the frog, premedicated with manganese chloride 30 mg/kg, is 0.16 mgjkg by B.K. method and 0.15mg/kg by V.D.W. method.
5. LD_(50) of Quabain to the frog, premedicated with manganese chloride 60 mg/kg is 0.15 mg/kg by B.K. method and 0.15 mg/kg by V.D.W. method.
The LD_(50) of Ouabain to the frog and the mice, premedicated with manganese chloride 30mg/kg and 60mg/kg are decreased than LDa of Ouabain only. But the difference between LD_(50) of Ouabain only and LD_(50) of Ouabain premedicated with Manganese chloride 30mg/kg to the mice is not so clear than to the frog.