Progesterone 및 Cortisone 多量 長期投與가 家兎子宮 및 副腎組織의 水分 및 電解質에 미치는 影響 = Experimental Study on Changes in Water Content and Electrolytes of the Uterus and Adrenal Gland Tissue in Castrated Rabbits by Large Amount Administration of Progesterone and Cortisone for the Long Period

다국어 초록 (Multilingual Abstract)

The author has attempted to clarify the effects of sex hormones on electrolytes in the tissue of uterus and adrenal gland of mature non-pregnant rabbits weighing about 2 ㎏. in body weight.
Determination of the water content and electrolyte levels of uterus, the target organ of sex hormone, and of adrenal gland of the normal, castrated and administration of progesterone 100 ㎎ and cortisone 25 ㎎ daily for two weeks after castration.
Particulary, the levels of Cl, Na, K, Ca, Mg and water content in the organ tissues mentioned in the foregoing were determined and changes in electrolyte levels and comparison of the electrolytes and water content in these organ tissues were undertaken after castration and after administration of progesterone and cortisone in large doses to castrated rabbits.
Water content was determined by drying method in 100℃ oven until the weight remained constant.
Flame-photometry was utilized for the determination of Na and K levels, Schales and Schales method for Cl contents and Kovacs and Tarrnoky's method for Ca and Mg contents.
The results obtained are summarized as follows:
1. Serum electrolyte levels of rabbits following castration produced no appreciable changes.
A long term administration of progesterone in large doses to castrated rabbits produced a increase in Ca level and a marked decrease in Mg level but did not induced restorations of electrolyte levels prior to castration.
A long term administration of cortisone in large doses to castrated rabbits produced a marked decrease in K, Ca and Mg levels.
2. Castration of female rabbits produced a increase in Cl level, a marked increase in Ca level and a marked increase in Mg level of uterine tissue.
A long term administration of progesterone in large doses to castrated rabbits produced a marked increase in Cl, K and Mg levels of uterine tissue. whereas a long term administration of cortisone in large doses to castrated rabbits produced a marked increase in Cl, Na, Ca and Mg levels of uterine tissue but did not induced restorations of electrolyte levels prior to castration.
3. Castration of female rabbits produced a marked increase in water content, a decrease in Cl level and a marked increase in levels of K and Mg of adrenal gland tissue.
A long term administration of progesterone in large doses to castrated rabbits produced a marked increase in K and Ca levels and a marked decrease in water content of adrenal gland tissue, whereas a long term administration of cortisone in large doses to castrated rabbits produced a increase in Na level, a marked increase in Cl, K, Ca and Mg levels and a marked decrease in water content of adrenal gland tissue but did not induced restorations of electrolyte levels prior to castration.
4. Water content in the uterine tissue produced no remarkable changes in castration, administration of progesterone and cortisone, whereas water content in the adrenal gland produced a marked increase in castration and a marked decrease in administration of progesterone and cortisone but did not induced restorations of water content prior to castration.
Water content of the adrenal gland tissue showed a marked decrease in comparison with that of the uterine tissue of normal, castrated, progesterone and cortisone administered female rabbits.
5. Cl content in the uterine tissue produced a increase in castration, a marked increase in administration of progesterone and cortisone, whereas Cl content in the adrenal gland tissue produced a decrease in castration, no remarkable changes in administration of progesterone and a marked increase in administration of cortisone.
Cl content of the adrenal gland tissue showed no remarkable change in normal and a marked decrease in comparison with that of the uterine tissue of castrated, progesterone and cortisone administered female rabbits.
6. Na content of the uterus and the adrenal gland produced no remarkable changes in castration and administration of progesterone, but Na content of the organs mentioned in the foregoing produced a marked increase in administration of cortisone, and then Na content increased than prior to the castration.
Na content of the adrenal gland tissue showed a marked decrease in comparison with that of the uterine tissue of normal, castrated, progesterone and cortisone administered female rabbits.
7. K content in the uterine tissue produced no remarkable changes in castration and administration of cortisone and a marked increase in administration of progesterone, whereas K content of the adrenal gland tissue produced a marked decrease in castration and a marked increase in administration of progesterone and cortisone but did not induced restorations of K content prior to castration.
K content of the adrenal gland tissue showed a marked increase in normal, progesterone and cortisone administered female rabbits and no remarkable changes in castrated female rabbits in comparison with that of the uterus.
8. Ca content in the uterine tissue produced a marked increase in castration, no remarkable changes in administration of progesterone and a marked increase in administration of cortisone.
Ca content in the adrenal gland tissue produced no remarkable changes in castration and a marked increase in administration of progesterone and cortisone.
Ca content of the adrenal gland tissue showed a marked increase in comparison with that of the uterus of normal, castrated, progesterone and cortisone administered female rabbits.
9. Mg content in the uterine tissue produced a marked decrease in castration and a marked increase in administration of progesterone and cortisone.
Mg content in the adrenal gland tissue produced a marked decrease in castration, no remarkable changes in administration of progesterone and a marked increase in administration of cortisone.
Mg content of the adrenal gland tissue showed a marked increase in normal and castrated female rabbits, a marked decrease in progesterone administered female rabbits and no remarkable changes in cortisone administered female rabbits in comparison with that of the uterus.

목차 (Table of Contents)

• Ⅰ. 緖論
• Ⅱ. 實驗材料 및 方法
• 1. 實驗動物
• 2. 去勢方法
• 3. Hormone 投與方法
• 4. 水分 및 電解質測定方法
• Ⅲ. 實驗結果 및 考按
• 1. 血淸電解質
• 2. 子宮組織內 電解質
• 3. 副腎組織內 電解質
• 4. 子宮 및 副腎組織內 水分量의 比較
• 5. 子宮 및 副腎組織內 Cl量의 比較
• 6. 子宮 및 副腎組織內 Na量의 比較
• 7. 子宮 및 副腎組織內 K量의 比較
• 8. 子宮 및 副腎組織內 Ca量의 比較
• 9. 子宮 및 副腎組織內 Mg量의 比較
• Ⅳ. 結論
• 參考文獻