사람 십자인대의 감각신경 지배 = Innervation of Human Cruciate Ligaments

다국어 초록 (Multilingual Abstract)

The knowledge of distribution of nociceptive and proprioceptive nerve fibers in cruciate ligaments in human knee joint would provide insight in understanding the sensory role of cruciate ligaments. Th ligaments have been mainly considered as mechanical and structural joint stabilize However, ligaments and other joint structures may serve as more refined sensors. The innewation of 24 human an rior and posterior cruciate ligaments obtained during total knee arthroplasty, mainly total knee arthroplasty, was studied. Immunocytochemical technique using monoc1 nal antibody to substance-P (SP), leucine-enke- phalin (leu-Ehk), neurofilament (NF) 00 and glial fibrillary acidic protein (GFAP) and acetylcholindsterase (AChE) histoche istry were employed to identify sensory nerve fibers. The nerve fibers and nerve ending were found in synovium, fat pad and intrafascicular connective tissue of cruciate ligaments. The nerve fiber was myelinated showing GFAP-immunoreactive and/or unmy inated showing GFAP-nonreactive. The nerve fiber was immunoreactive to SP, leu-E k and NF 200 and had terminal nerve structures with free nerve endings providing noc' eption and supplying blood vessels, Ruffini cor- puscles and 'Pacinian cofpuscles. Bat of the corpuscles were known to be mechanozeceptors. These three kind of nerve e dmgs were observed in all cruciate ligaments and distributed denser in both end of cr ciate ligaments. AChE-positive nerve fibers and Ruffini corpuscles were observed, m re common in posterior cruciate ligament than anterior. In intrafascicular space of c uciate ligament, Pacinian corpuscles was noted, but other t%o neirve endings not, Gal organ was not found in every cruciate ligament. The pre8ence of nociceptive recep ors and nerve fibers in the anterior and posterior cruciate ligspents were confirmed by a immunocytochemical method using monoclonal antibody for SP, leu-Enk, NF 200 nd GFAP and AChE histochemistry.