尿路系感染菌의 抗菌性物質耐性 및 이들 物質投與가 耐性 및 尿中菌數에 미치는 影響 = Resistance to Antibacterial Substances and the Effect on the Administration of These Substances on Urinary Pathogenus

국문 초록 (Abstract)

尿路系 感染症患者에서 菌檢出을 試圖하고 分離菌의 抗菌性物質耐性 및 이들 物質 投與가 菌의 耐性 및 尿中菌數에 미치는 影響을 보았다.
尿中에서 葡萄球菌, 大陽菌, Klebsiella, Enterobacter, Alkaligenes, Proteus, Serratia, Pseudomonas등이 分離되었는데 大部分이 chloramphenocol, tetracycline(TC), streptomycin, sulfonamide, penicillin, ampicillin(AP), kanamycin, erythromycin, carbenicillin에 耐性이었고 gentamicin(GM)에만 感受性이었으나 Pseudomonas는 GM에도 耐性이었다.
Doxycycline, AP, KM 등의 投與에 依하여 TC, AP 또는 KM에 耐性인 Klebsiella, Enterobacter, Alkaligenes등도 尿中菌의 消失 또는 減少를 招來했으나 Pseudomonas는 이들 物質은 勿論, GM投與도 菌消失을 招來하지 못하였다. 分離菌은 大部分이 實驗初期부터 抗菌性物質에 耐性이었으며 따라서 이들 抗菌性 物質投與가 耐性을 더 以上 上昇시키지는 않았다.
大腸菌의 第 2次 感染을 볼 수 있었으며 이 感染菌은 抗菌性物質에 耐性이 强하였고 Pseudomonas의 感染도 院內에서 일어나는 일이 많으며 抗菌性物質에 耐性이 强하였다.

다국어 초록 (Multilingual Abstract)

The resistance to antibacterial substances of urinary pathogens and the effect of the adminstration of antibacterial substances on the resistance and bacterial counts in urines were studied.
Staphylococcus, Escherichia coli, Klebsiella, Enterobacter, Alkaligenes, Proteus, Serratia, and Pseudomonas were isolated from urines of patients suffering from urinary infection. Most strains were resistant to chloramphenicol, tetracycline, streptomycin, sulfonamide, penicillin, ampicillin (AP), kanamycin (KM), erythromycin and carbenicillin, and sensitive to gentamicin (GM), but all strains of Pseudomonas were resistant to these susbstances including GM. The adminstration of doxycycline, a derivate of tetracyclines, AP and KM resulted in the disappearance of diminution of Klebsiella, Enterobacter and Alkaligenes in urines, but the bacterial counts of Pseudomonas in urines were not influenced by the use of these drugs and even by GM. Strains of first isolation from the same patients were resistant to the antibacterial substances, and the use of these substances did not result in the marked increase in the resistance of causative agents.
The secondary infections of E.coli and Pseudomonas were noted, and these were considered to be nosocomial infections. The strains were also highly resistant to antibacterial substances used, and the prevention of secondary hospital infection was emphasized.