(The)effects of trimetazidine in a porcine myocardial infarction model : evaluation with multi-detector computed tomography = 돼지 심근경색 모형에서 트리메타지딘의 효과 : 다중검출기 CT를 이용한 평가

다국어 초록 (Multilingual Abstract)

Background and objectives: There are increasing evidences suggesting the trimetazidine (TMZ) has the ability to improve ischemic heart failure by way of the optimization of energy metabolism. The aim of this study was to examine the changes of myocardial enhancement pattern on the two-phase, contrast enhanced, ECG-gated, multi-detector computed tomography (MDCT) after administration of TMZ in porcine myocardial infarction model. Subjects and Methods: Porcine myocardial infarction model was made by balloon occlusion of the left anterior descending coronary artery. The swines were randomized into two groups: group I (n=7: aspirin 100 mg administered only), group II (n=7: aspirin 100 mg plus 1 mg/kg TMZ administered for 4 weeks). Echocardiography and MDCT were performed. Ejection fraction (EF, %), end-systolic volume (ESV, mL) and end-diastolic volume (EDV, mL) were measured at 4 weeks after induction of myocardial infarction. Three enhancement pattern including early arterial phase defect (ED), 4-min late enhancement (LE) or residual defect (RD) were also investigated and those were described as class I [ED (-), RD (-), LE (？)], class II [ED (+), RD (-), LE (+)], and class III [ED(+), RD (+), LE (+)].
Results: Baseline and follow-up echocardiography at 4 weeks after the induction of MI demonstrated no significant differences between the two groups. The data of LV indices by MDCT were also similar between the two groups (group I: EF:ESV:EDV = 46.0？12.5% : 35.9？23.0mL : 69.0？40.2mL, group II: EF:ESV:EDV = 49.8？13.2% : 43.8？23.1mL : 82.8？24.6mL, p=NS). Percent wall thickness of LV was similar (69.1？19.6% vs. 64.9？10.5%, p=NS), but the enhancement pattern was different between the two groups (group I-class I: II: III = 0 (0 %) : 0 (0 %) : 7 (100 %), group II？class I: II: III = 0 (0 %) : 2 (28.6 %) : 5 (71.4 %), p<0.001). The volume of tissue that lacking triphenyl tetrazolium chloride was similar between the two groups (8.4？1.9% vs. 7.3？2.6%, p=NS). Conclusion: TMZ administration produced different enhancement patterns in MDCT. This result suggests that TMZ administration can reduce residual defect in porcine myocardial infarction model. To our best knowledge this is the novel observation that beneficial effect of TMZ could be proved by MDCT.

목차 (Table of Contents)

• I. Abstract 1
• II. Introduction 3
• III. Materials and Methods 5
• IV. Results 10
• V. Discussion 12
• VI. Conclusion 16
• VII. References 17
• VIII. Korean abstract 23
• IX. Tables and Figures 25