家兎 頭蓋內壓上昇時 血壓上昇에 미치는 Clonidine 및 Regitine의 影響 = Effect of Clonidine and Regitine on the Pressor Reoponse to Raised Intracranial Pressure in Rabbits

국문 초록 (Abstract)

1) Urethane 麻醉家兎에서 頭蓋內壓上昇에 따른 血壓上昇의 成立機轉을 알기 위하여 本實驗을 하였다.
2) 側腦室內 clonidine의 注入은 頭蓋內壓上昇에 依한 血壓上昇을 顯著히 抑制하였다.
3) Regitine의 側腦室內 注入은 clonidine에 依한 上記 血壓上昇의 抑制에 對하여 拮抗效果를 나타냈다.
4) Reserpine 處理家兎에서는 頭蓋內壓 上昇에 따른 血壓上昇은 나타나지 않았으나 NE의 側腦室內 注入後에는 나타났다.
5) 側腦室內에 NE 注入을 한 reserpine 處理家兎에서 볼 수 있었던 頭蓋內壓上昇에 依한 血壓上昇은 clonidine 注入後에는 나타나지 않았다.
6) 頭蓋內壓上昇은 腦內의 어떠한 部位를 興奮시켜 norepinephrine 遊離의 增加를 일으킴으로써, 中樞부터의 sympahtetic outflow를 增加시켜 血壓을 上昇시키는 것으로 推論하였다.

다국어 초록 (Multilingual Abstract)

1. It was attempted to clarify the mechanism of the pressor response to raised intracranial pressure in urethane-anesthetized rabbits.
2. Intraventricular clonidine markedly inhibited the pressor response to raised intracranial pressure.
3. Intraventricular regitine antagonized the above mentioned inhibitory effect of clonidine on the pressor response.
4. In reserpine-treated rabbits the pressor response to raised intracranial pressure was not observed, whereas after the intraventricular administration of norepinephrine the pressor response was observed.
5. Intraventricular clonidine inhibited the pressor response that could be observed in the reserpine-treated rabbits after the intraventricular norepinephrine.
6. It is inferred that raised intracranial pressure stimulated some part of the brain to cause the increase of norepinephrine release, resulting in the increase of the sympathetic outflow and the elevation of blood pressure.