頭腦外傷 患者에서 腦脊髓液의 Glutamic Oxalacetic Transaminase와 Lactic Dehydrogenase變動에 關한 硏究 = Glutamic Oxalacetic Transaminase and Lactic Dehydrogenase in Cerebrospinal Fluid and Serum of Patients with Craniocerebral Injuries

다국어 초록 (Multilingual Abstract)

Clinical and experimental studies have shown that destruction of central nervous system parenchyma is associated with increases activity of the enzyme glutamic oxalacetic transaminase (GOT) and lactic dehydrogenase (LDH) in the cerebrospinal fluid. Cohen and Hekhuis demonstrated in 1941 that the brain had a high rate of transamination when compared with other body tissue, Wakim and Fleisher produced experimental cerebral infarction in dogs and found a significant increase in the spinal fluid transaminase. A4iyazaki also demonstrated an increase in spinal fluid transaminase activity after cerebrovascular strokes. Recently Vara-Lopez and Vara-Thorbeck suggested that a study. of these enzymes in the CSF had diagnostic value in the study of patients in whom an intracranial tumor was suspected.
The study herein presented was undertaken to determine whether craniocerebral injuries would result in increased GOT and LDH activities of the spinal fluid and. serum.
We have investigated the. activity of some enzymes. GOT and LDH in the spinal fluid obtained by lumbar puncture and in the serum from 79 patients with craniocerebral injuries and from 16 healthy persons (control group) who were admitted to the Department of Neurosurgery, Korea University Medical College from February to August, 1972.
The normal levels of GOT and LDH activity in the spinal fluid were 2-J4 units and 0-40 units per milliliter respectively. Significantly higher enzyme levels have been found in the spinal fluid of patients with craniocerebral injuries as compared with normal individuals. Pathological increase of the levels of GOT and LDH activity in patients with craniocerebral injuries were 26.3044.41 units and 35.30-127. 1 units per milliliter respectively.
The level of enzyme activity are increased in proportion to the severity of craniocerebral injuries, and the, bloody spinal fluids are generally associated with more marked elevation of the activity than that in clear spinal fluid even in same group of patients.
In Group IV, patients in coma or with intracranial hematorna, the level of the activity are elevated in both spinal fluid and serum, but the value in the serum are not pathological in extent.
The mean level of the activity in the spinal fluid in the male patients with craniocerebral injuries is slightly higher than that in the females.