건선병변에 대한 직접 면역형광 검사에 관한 연구 = Direct Immunoflourescent Test of Psoriatic Lesions

국문 초록 (Abstract)

건선의 면역학적 발생기전을 규명코자 하는 연구의 일환으로 임상적으로 전형적인 건선병변을 보인 27예를 대상으로, 직접 면역형광검사를 시행하였다. 27예 중 15예(56%)에서 Immunoglobulin(이하 Ig)이나 보체가 침착되었고, 그 중 IgG(80%), IgA(53%)가 가장 많이 침착되었으며 14예(93%)에서는 각질층에 침착되었다.

다국어 초록 (Multilingual Abstract)

In order to study the immunologic pathogenesis of psoriasis, direct immunofluorescent test was performed on 27 patients, comprising of 17 with psoriasis vulgaris and 10 with pustular psoriasis. Biopsy specimens were taken primarily from involved skin, although in 8 patients with psoriasis vulgaris, biopsy was done on uninvolved skin also.
The results were as follows :
1.Positive immunofluorescent findings were obtained in 15 of the 27 patients ; 10 of 17 patients with psoriasis vulgaris and 5 of 10 patients with pustular psoriasis.
2.Among 15 positive cases, IgG was present in 12 cases (80%), IgA in 8 cases (53%), IgM in 5 cases (33%), C3 in 5 cases (33%) and C4 in 3 cases (20%).
3.Deposition of Is and / or complement were found at stratum corneum in 14 of 15 positive cases and one in blood vessel wall.
4.No deposits of Ig or complement were found in clinically uninvolved skin in 8 patients with psoriasis vulgaris

목차 (Table of Contents)

• 서론
• 대상 및 방법
• 1.대상
• 2.방법
• 성적
• 1.직접 면역형광 검사의 양성률 및 부위
• 2.침착된 Ig 및 보체의 종류
• 고찰
• 결론