Prostaglandin F₂α와 Progesterone이 家兎子宮 및 胃組織의 Catecholamine 含量에 미치는 影響 = An Experimental Study of the Effects of Prostaglandin F₂α and Progesterone on the Catecholamine Content in Uterine and Stomach Tissue of Mature Female Rabbits.

다국어 초록 (Multilingual Abstract)

Prostaglandin F₂α has been studied by many scholars and used for induction of labor which is supposei to be far superior to any preexisting agent or method. Despite the fact that few patients experience allergic reactions, hypertension, bronchospasm, nausea, vomiting, cramps, and diarrhea, the efficacy and relative safety of the drug establish it as superior to intra-amniotic instillation of hypertenic saline.
Prostaglandins are formed from free essential fatty acids within the cell in a sequence of complex enzyme reactions, and they are released in response to nervous, chemical, and mechanical stimuli.
An attempt was made to clarify the effects of prostaglandin F₂α and progesterone on the catecholamine content in uterine and stomach tissue of mature female albino rabbits weighing approximately 2.0 ㎏.
A group of albino rabbits was conditioned with 100 ㎍/㎏ of prostaglandin F₂α and another group with 50 ㎎/㎏ of progesterone.
Catecholamine content was determined by Shore and Olin method and the results obtained were as follows :
1. The catecholamine content in normal uterine tissue was 0.33±0.06 ㎍/gm while that of stomach tissue was 0.06±0.02 ㎍/gm. It showed that the catecholamine content in uterine tissue was higher than in stomach tissue.
2. In prostaglandin F₂α conditioned group, the catecholamine content in uterine tissue was 1.25±0.54 ㎍/gm, while that of stomach tissue was 0.13±0.08 ㎍/gm. It was, therfore, shown that the catecholamine content in uterine tissue was increased significantly, while that of stomach tissue showed slight increase in prostaglandin F₂α conditioned group.
3. In progesterone conditioned group, the catecholamine content in uterine tissue was 0.21±0.06 ㎍/gm and its content in stomach tissue was 0.09±0.02 ㎍/gm.
The catecholamine content in uterine tissue showed marked decrease in progesterone conditioned group and showed, even more, decrease compared with prostaglandin F₂α conditioned group. There was a slight increase in stomach in progesterone conditioned group than normal control group, however, there was no significant change compared with prostaglandin F₂α conditioned group.
4. The catecholamine content in uterine tissue was markedly increased in prostaglandin F₂α conditioned group, while there showed decrease in progesterone conditioned group.
5. The catecholamine content in stomach tissue showed marked increase in prostaglandin F₂α conditioned group, and, also, showed increase in progesterone group.
6. The catecholamine content in uterine tissue was higher than that of stomach tissue in normal control group.
There was a marked increase in uterine tissue in prostaglandin F₂α conditioned group, and, also, showed increase in stomach tissue.

목차 (Table of Contents)

• Ⅰ. 緖論
• Ⅱ. 實驗資料 및 方法
• 1. 實驗動物
• 2. Prostaglandin F₂α(PGF₂α) 와 Progesterone 投與方法과 子宮 및 胃組織의 探取方法
• 3. Catecholamine 含量의 測定方法
• Ⅲ. 實驗成績
• 1. 正常子宮 및 胃組織의 Catecholamine 含量
• 2. PGF₂α 投與後 子宮 및 胃組織의 Catecholamine 含量
• 3. Progesterone 投與後 子宮 및 胃組織의 Catecholamine 含量
• 4. 子宮組織에서의 正常群, PGF₂α 投與群 및 Progesterone 投與群의 Catecholamine 含量의 比較
• 5. 胃組織에서 正常群, PGF₂α 投與群 및 Progesterone 投與群의 Catecholamine 含量의 比較
• 6. 子宮 및 胃組織에서 正常群, PGF₂α 投與群 및 Progesterone 投與群의 Catecholamine 含量의 比較
• Ⅳ. 考按
• Ⅴ. 結論
• 參考文獻