경기도 (京機道) 동두천읍 (東豆川邑) 송내리에 (松內里) 유행한 (流行) 한국형 (韓國型) 출혈열의 (出血熱) 역학적 (疫學的) 조사 (調査)

다국어 초록 (Multilingual Abstract)

Epidemic hemorrhagic fever with renal syndrome was recognized for the first time in Korea in 1951 among United Nation troops. Since that time it has been known as Korean hemorrhagic fever (KHF) and has remained endemic near the Demilitarized Zone between North and South Korea. In recent years the disease has invaded the southern parts of the Korean peninsula and 100 to 800 hospitalized cases are clinically diagnosed each year. Similar diseases to KHF have been described by Japanese from Manchuria, from the Soviet Union, from several countries in Eastern Europe and recently from Japan. In 1976 Lee and Lee successfully demonstrated an antigen in the lungs of the striped field mouse, Apodemus agrarius coreae, which gave sepecific immunofluorescent reaction with sera from patients convalescent from KHF and named it as Korea antigen. Very recently, Lee et al, have reported that this antigen is the etiologic agent of KHF for the first time, and convalescent sera from hemorrhagic nephroso-nephritis in the Soviet Union, from nephropathia epidemica in Scandinavia and from epidemic hemorrhagic fever in Japan were positive for antibodies to KHF virus. It is noteworthy achievement to cite that Lees method o#f serologic diag#nosis of KHF has made s#tudy o#f sero-epidemiology o#f KHF and related diseases possible. The report describes a localized outbreak of KHF in Songnaeri, Tongduchun, Kyunggido in 1971 and results of sero-epidemiologic study of the epidemic for the first time. There were 9 patients with typical clinical symptoms of KHF among 1,171 residents of Songnaeri during the outbreak of KHF from October 1,1971 to end of November 1971 and attack rate was 0.8%. Eight patients out of 9 cases were farmers in age group of over 20, and male and female attack rates were 0.8% and 0.7%, respectively, It was demonstrated for the first time that all of the patients had contained significant amounts of antibodies to KHF virus in the sera after 5 years from KHF. There was no reinfection of KHF among the persons who recovered from illness.