加味大補湯이 白鼠의 血壓에 미치는 影響 = Effects of Kamitaebotang on Blood Pressure

국문 초록 (Abstract)

現代 成人病 중에서 가장 根本이 되는 基礎的 原因疾患으로서, 最近 食生活의 向上, 公害의 增加, 精神的 緊張의 增加로 인해 腦卒中, 動脈硬化, 糖尿病 등의 疾患과 더불어 增加趨勢에 있는 高血壓에 대하여 氣血大虛로 因한 中風의 左半身 或 右半身不遂 및 高血壓의 症狀에 有效한 治療效果가 있다고 思料되는 加味大補湯의 고혈압 억제 작용을 SD를 통하여 검토하였던 바 加味大補湯은 低濃度에서 血壓 降下作用이 있고 高濃度에서는 血壓에 影響을 주지 않으며, 血壓降下作用이 交感神經 α2 및 α受容體 遮斷制에 의해 遮斷되었으므로 交感神經遮斷劑로서의 役割을 하는 것으로 判斷되나 앞으로 用量의 變化에 따른 血壓에 미치는 影響과 血壓降下의 機轉에 대한 깊은 硏究가 必要하리라 思料된다.

다국어 초록 (Multilingual Abstract)

A study on the Effect of KAMITAEBOTANG(加味大補湯) on the Blood Pressure in SD Rats.
The results were obtained as follows ;
1. In the result of Administration of KTBT for 11 days in SD Rats, the Blood Pressure was decreased in 150㎎/㎏, 300㎎/㎏ of solid extract of KTBT, unchanged or increased in 600㎎/㎏, 1200㎎/㎏ of solid extract of KTBT, KTBT had no effects on Pulse Rate at all treated group.
2. After injection of KTBT on caudal vein of SD Rats, the Blood Pressure was
decreased in 150㎎/㎏, 300㎎/㎏ of solid extract of KTBT, unchanged or increased in 600㎎/㎏, 1200㎎/㎏ of solid extract of KTBT, and KTBT had no effects on Pulse Rate to all treated group.
3. The antihypertensive effect of KTBT was obliterated by pretreating with Clonidine 0.2㎎/㎏, Adrenergic α2 recepter Blocking Agent, and KTBT had no effect on Pulse Rate to all treated group.
4. The antihypertensive effect of KTBT was obliterated by pretreating with
Pentolamine 1.0㎎/㎏, Adrenergic α recepter Blocking Agent, and KTBT had no effect on Pulse Rate to all treated group.
5. The antihypertensive effect of KTBT was not obliterated by pretreating with
Propranolol 1.0㎎/㎏, Adrenergic β recepter Blocking Agent, and KTBT had no effect on Pulse Rate to all treated group.
6. The antihypertensive effect of KTBT was not obliterated by pretreating with
Hydralazine 2.0㎎/㎏, Vasodilating Agent, and KTBT had no effect on Pulse Rate to all treated group.
7. The antihypertensive effect of KTBT was not obliterated by pretreating with
Verapamil 1.5㎎/㎏, Ca++Blocking agent, and KTBT had no effect on Pulse Rate to all treated group.
From the above result, blood pressure was decreased in the lower concentration of KTBT, unchanged or increased in the more concentration of KTBT. Because the
antihypertensive effect of KTBT was obliterated by pertreateing with Adrenergic α2, αrecepter Blocking Agent, the antihypertensive mechanism of KTBT is supposed be Adrenergic α2, α recepter Blocking Agent. And further study on the effect on the Blood Pressure and the antihypertensive mechanism of KTBT on accordance with concentration should be ensured.