항암제 CLA의 기능성 농·축·수산물 생산을 위한 신 기능성소재로서의 역할 = Role of Conjugated Linoleic Acid (CLA) as a New Functional Substance for Agricultural and Marine Products

국문 초록 (Abstract)

Conjugated linoleic acid (CLA)는 여러 동물실험에서 항암성을 나타내었다. 항암성 외에도 CLA는 항동맥경화 효과, 면역촉진 효과, 체지방감소 효과와 같은 생리활성을 나타내었다. 주요 CLA source는 반추동물로부터 유래되는 고기 (쇠고기 등)와 유제품이다. 최근 이러한 생리 활성을 갖는 CLA를 사효첨가제 또는 식품첨가제로 이용하여 CLA-달걀, CLA-닭고기, CLA-돼지고기, CLA-쇠고기, CLA-우럭, CLA-새우, CLA-감자 등과 같은 여러가지 기능성 농·축·수산물을 생산하는 연구가 수행되고 잇다. CLA는 생체 내에서 함암성과 같은 생리활성을 나타냄은 물론, 기능성 식품에서 cholesrerol의 함량감소, 지방감소 및 저장성 증진효과를 나타내었다. 특히 CLA는 우럭종묘의 활력을 증가시켰다. 그러나 CLA의 합성단가가 높아, CLA 함유 기능성 식품 생상네는 고비용이 소요되고 있다. 따라서 CLA의 생산단가를 낮출 수 있는 연구가 수행되어야 할 것이다.

다국어 초록 (Multilingual Abstract)

Conjugated linoleic acid (CLA) exhibited anticarcinogenic activity for several animal models:7,12-dimethylbenz-［a］anthracene (DMBA)-induced mouse epidermal carcino-genesis, benzo［a］pyrene (BP)-un-duced mouse forestomach tumorigenesis, DMBA-induced rat mammary carcinogenesis, 2-amino-3-methylimidazo［4,5-f］euinoline (IQ)-induced rat colon carcinogenesis, and S-180 in-duced mouse ascites cancer. In addition, CLA showed activities of anti-atherosclerosis, immune stimulation, and body fat reduction in animal models and human as well. Major sources of CLA was meats and dairy products derived from ruminant animals. currently, lots of attempts have being conducted to produce CLA-containing functional products of agricultures, meats and marine fish by dietary CLA or adding CLA during prcessings. The typical CLA-containing functional products were eggs (CLA-eggs), chickens (CLA- chickens), porks (CLA-porks), beef patties (CLA-beef patties), eels (CLA-eels), rockfish (CLA-rockfish), shrimps (CLA-shrimps) and potatoes (CLA-potatoes). The functions of CLA in these products were appeared to be the reduction of cholesterol content in CLA-eggs, CLA-porks and CLA-shrimps, reduction of total fat content in CLA-porks, exten- sion of storage stability in CLA-pork and CLA-beef patties, enhancement of survival rate of rockfish seeds in CLA-rockfish, and inhibition of browning reaction in CLA-potatoes. One of shortcomings for the production of these functional products was found to be the high cost for manufacturing CLA from plant seed oils containing relatively higher linoleic acid; hence, methods to synthesize CLA at lower cost should be developed for utilization of CLA as feed ingredients. We believe that functionally active CLA-containing agri-cultural, animal and marine products should appear on market soon.