KCI등재
패혈증에서의 TNF - α의 변화와 장기 손상의 상관관계와 상정호르몬의 치료효과 = Relationship between organ Injury and TNF - α in Sepsis and Therapeutic effect of Growth Hormone
저자
발행기관
학술지명
권호사항
발행연도
1996
작성언어
Korean
KDC
514.000
등재정보
KCI등재
자료형태
학술저널
수록면
18-32(15쪽)
제공처
소장기관
Multi-organ failure from sepsis is very lethal disease entity, which is suspected to be caused by the injury by oxygen radicals generated in the septic condition. As mediators of inflammatory reactions, oxidants and cytokines such as TNF- stimulates macrophages and neutrophils, and causes systemic inflammatory reactions. Recently, some reported that GH(growth hormone) has been clinically used in septic patients with beneficial therapeutic effects, but the mechanisms of these effects don,t have been explained exactly.
This study is designed to evaluate the therapeutic effects of GH in sepsis. For this purpose, the suppresive effects of GH on hepatic and pulmonary injury in sepsis induced by zymosan were examined, and the relation of this effects with antioxidant mechanism and cytokines was investigated in this experiment.
Methodologically, female Sprague-Dawley rats as experiment animal were injected intraperitoneally with zymosan to simulate experimental sepsis model, and then their liver and lung tissue were examined histopathologically, and malondialdehyde(MDA) level and catalase activity of the liver and lung tissue were measured biochemically. TNF level in the blood of the rats were measured with ELISA method to evaluate the mechanism of the therapeutic effect of GH on sepsis. The rats were devided into 3 groups, that is a control group, a zymosan-injected group(500 mg/kg intraperitoneal injection, mixed with mineral oil), and a zymosan & recombinant human GH-injected group(2.0 I.U./kg intramural injection). Each group except control group(8 rats) had 40 rats, and every 8 rats were sacrificed and sampled at 6 hours, 12 hours, 24 hours, 48 hours, and 72 hours after injection.
The results are as follows.
On pathological examination, liver tissue of the zymosan-injected group showed lymphocyte and neutrophil infiltration, fatty degeneration of hepatocyte, and destruction of liver lobular structure. Lung tissue of the same group showed lymphocyte and neutrophil infiltration and interstitial edema. There were lesser degree of lymphocyte and neutrophil infiltration and lesser structural injury in the liver and lung tissue of the zymosan & GH-injected group than the zymosan only-injected group.
Plasma TNF- levels of the zymosan-injected group were markedly increased compared with the control group, and reached peak level between 24 hours and 48 hours after injection.
Plasma TNF- levels were significantly suppressed in zymosan & GH-injected group.
MDA levels of liver and lung tissue were remarkably increased in the zymosan-injected group, compared with the control group. The zymosan & GH-injected group had lower MDA levels than the zymosan-injected group. There were statistically significant differences in both liver and lung tissues.
So far as catalase activity, lung had higher catalase activity than liver in the control group, and catalase activity was markedly reduced in the zymosan-injected group. In the zymosan & GH-injected group, there were statistically significant increases of catalase activity as compared with zymosan-injected group.
Conclusively, CH had therapeutic effect on the organ failure induced by zymosan. GH was demonstrated to have suppressive effect on the lipid peroxidation, and this effect was supposed to be related to increase of catalase activity. And GH was found to have inhibitory effect on the production of TNF-a, a cytokine which mediates tissue injury in sepsis.
서지정보 내보내기(Export)
닫기소장기관 정보
닫기권호소장정보
닫기오류접수
닫기오류 접수 확인
닫기음성서비스 신청
닫기음성서비스 신청 확인
닫기이용약관
닫기학술연구정보서비스 이용약관 (2017년 1월 1일 ~ 현재 적용)
학술연구정보서비스(이하 RISS)는 정보주체의 자유와 권리 보호를 위해 「개인정보 보호법」 및 관계 법령이 정한 바를 준수하여, 적법하게 개인정보를 처리하고 안전하게 관리하고 있습니다. 이에 「개인정보 보호법」 제30조에 따라 정보주체에게 개인정보 처리에 관한 절차 및 기준을 안내하고, 이와 관련한 고충을 신속하고 원활하게 처리할 수 있도록 하기 위하여 다음과 같이 개인정보 처리방침을 수립·공개합니다.
주요 개인정보 처리 표시(라벨링)
목 차
3년
또는 회원탈퇴시까지5년
(「전자상거래 등에서의 소비자보호에 관한3년
(「전자상거래 등에서의 소비자보호에 관한2년
이상(개인정보보호위원회 : 개인정보의 안전성 확보조치 기준)개인정보파일의 명칭 | 운영근거 / 처리목적 | 개인정보파일에 기록되는 개인정보의 항목 | 보유기간 | |
---|---|---|---|---|
학술연구정보서비스 이용자 가입정보 파일 | 한국교육학술정보원법 | 필수 | ID, 비밀번호, 성명, 생년월일, 신분(직업구분), 이메일, 소속분야, 웹진메일 수신동의 여부 | 3년 또는 탈퇴시 |
선택 | 소속기관명, 소속도서관명, 학과/부서명, 학번/직원번호, 휴대전화, 주소 |
구분 | 담당자 | 연락처 |
---|---|---|
KERIS 개인정보 보호책임자 | 정보보호본부 김태우 | - 이메일 : lsy@keris.or.kr - 전화번호 : 053-714-0439 - 팩스번호 : 053-714-0195 |
KERIS 개인정보 보호담당자 | 개인정보보호부 이상엽 | |
RISS 개인정보 보호책임자 | 대학학술본부 장금연 | - 이메일 : giltizen@keris.or.kr - 전화번호 : 053-714-0149 - 팩스번호 : 053-714-0194 |
RISS 개인정보 보호담당자 | 학술진흥부 길원진 |
자동로그아웃 안내
닫기인증오류 안내
닫기귀하께서는 휴면계정 전환 후 1년동안 회원정보 수집 및 이용에 대한
재동의를 하지 않으신 관계로 개인정보가 삭제되었습니다.
(참조 : RISS 이용약관 및 개인정보처리방침)
신규회원으로 가입하여 이용 부탁 드리며, 추가 문의는 고객센터로 연락 바랍니다.
- 기존 아이디 재사용 불가
휴면계정 안내
RISS는 [표준개인정보 보호지침]에 따라 2년을 주기로 개인정보 수집·이용에 관하여 (재)동의를 받고 있으며, (재)동의를 하지 않을 경우, 휴면계정으로 전환됩니다.
(※ 휴면계정은 원문이용 및 복사/대출 서비스를 이용할 수 없습니다.)
휴면계정으로 전환된 후 1년간 회원정보 수집·이용에 대한 재동의를 하지 않을 경우, RISS에서 자동탈퇴 및 개인정보가 삭제처리 됩니다.
고객센터 1599-3122
ARS번호+1번(회원가입 및 정보수정)