Flavonoids as therapeutic candidates for emotional disorders such as anxiety and depression

다국어 초록 (Multilingual Abstract)

Emotional disorders such as anxiety and depressionare widespread psychological diseases that affect up to20% of the world’s population. There are many approachesto the discovery of novel agents for the treatment of depressive-and anxiety-like symptoms. However, the efficacy ofexisting drugs for emotional disorders is only exerted after afew weeks of treatment and have serious side effects. Due tothis, new strategies to find suitable and safe options are beingsought by many researchers. Among them, a lot of interesthas been attracted by plant-derived natural compounds dueto their wide range of beneficial effects for new agent development.
Flavonoids are natural polyphenol-like compoundsfound commonly in plants, fruits, vegetables, and medicinalherbs. A diverse range of flavonoids have been studiedto investigate their potential therapeutic activities for thetreatment of brain-associated disorders, including anxietyand depression. The main aim of this review is to understandthe associations between the various flavonoids andthe emotional disorders and discuss the therapeutic effectsof these natural compounds that were demonstrated duringthe conduction of recent studies. The current work showsadvances in the latest research of some flavonoids as a potentialcandidate for the treatment of emotional disorders. Wesummarize their behavioral, molecular, physiological, andneurochemical effects in various in vitro and in vivo models.
Therefore, in the present work, the latest studies werecollected on the most important flavonoid compounds and their underlying mechanisms of action in emotion-relateddisorders were discussed.

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