각종 간질환에 있어서 간염 B 바이러스의 혈청학적 표식자들과 간조직의 HBsAg 에 관한 연구 = A Stduy on Serological Markers of Hepatitis B Virus and HBsAg in Liver Tissues of Various Lever Kiseases각종 간질환에 있어서 간염 B 바이러스의 혈청학적 표식자들과 간조직의 HBsAg 에 관한 연구

다국어 초록 (Multilingual Abstract)

The authors carried out to determine serological markers of hepatitis B virus (HBV) and to examine HBsAg in livor tissues in 14 cases of acute hepatitis (AH), 10 cases of chronic persistent hepatitis (CPH), 37 cases of chronic active hepatitis (CAH), 37 cases of liver cirrhosis (LC), and 24 cases of hepatocellular carcinoma (HC). Diagnosis were confirmed histopathologically in all patients. Blood samples and liver biopsy materials of a total 122 cases were obtained during the period from January, 1981 to May, 1984 in Pusan Paik Hospital, Inje College. Serum HBsAg and anti-HBs were tested by passive hemagglutination method. HBeAg, anti-HBe, and anti-HBc were tested by radioimmunoassay. HBsAg in liver tissues was histochemically examiined with Shikata's orcein method. The results obtained were as follows: 1. In AH and CAH, HBV serological markers could be detected anti-HBc, HBsAg, HBeAg, and anti-HBe and/or anti-HBs in descending order, and in CPH, LC, and HC, those could be detected anti-HBc, HBsAg, anti-Hbe, EiReAg, and anti-HBs in descending order. 100.% of AH and CPH, 94.6% of CAH and LC, and 95.8% of HC had the serological evidence cf either a current or past HBV infection. 3. The most common pattern of HBV serological markers was pattern III in AH, CAH, and LC, pattern VII in CPH, and pattern VI in HC. 4. HBsAg detecting rates in liver tissues were 21.4% in AH, 20.0% in CPH, 29.8% in CAH, 32.4% in LC, and 29.2% in HC. HBsAg in liver tissue was detected in about half of patients with srum HBsAg positive various livcr diseases. 6.HBsAg in liver tissues could be detected more frequently in pattern III in AH, CPH, and CAH and in pattern VI in LC and HC, as compared with other patterns. On the basis of these findings, it was suggested that HBV might play an important role in causation of most cases of various liver diseases in Korea and in order to investigate the relation of HBV infection to liver diseases, it is important to examine HBV markers in both serum and liver tissue.