KCI등재
흰쥐의 위산 분비 및 실험적 괴양에 미치는 향정신성물질의 영향 = EFFECT OF PSYCHOTROPIC AGENTS ON ACID SECRETION AND EXPERIMENTALLY INDUCED ULCER OF STOMACH IN RAT
저자
白尙昌 (서울大學校 大學院 神經精神科學敎室)
발행기관
학술지명
권호사항
발행연도
1974
작성언어
Korean
KDC
513.85
등재정보
KCI등재
자료형태
학술저널
발행기관 URL
수록면
61-71(11쪽)
제공처
소장기관
Introduction of psychotropic agents to the field of psychiatry brought tremendous change and new implication in the therapeutic aspect as well as the concept of psychosomatic medicine.
Reserpine was introduced by Sen & Bose(1931), and Vakil(1949) and Hakim(1953) has proved it to release biogenic amine (serotonin, norepinephrine, epinephrine, dopamin) at brain cell and peripheral tissues.
Chlorpromazine was proved to have tranquilizing effect by Laborit et al(1952), and tremendons therapeutic effect to treat the psychiatric patient was shown by Delay (1952 a&b) and Courvoisier(1653).
Jn 1961, Gey and Pletscher, and Axelrod found that chlorpromazine reduced the
permeability of granular membrane, where the biogenic amine was stored. Haloperidol, a derivative of butyrophenone was synthesized by Janssen(1958).
In 1966 Glowinski and Axelrod and in 1967 Janssen and Schildkraut et.al. reported that haloperidol reduced the shift of catecholamine from neuron and granular membrane.
Meprobamate, one of the minor tranquilizers, has been used widely as an antianxiety agent and antiulcer agent as well. But recently it seemed that the derivatives of benzodiazepine replaced meprobamate as antianxiety and antiulcer agent.
In 1952, Delay reported the iproniazid showed anti-depressive effect and Zeller explained that iproniazid had M.A.O. inhibitory action (1952).
In 1958, Kuhn reported imipramine, which has similar chemical structure of phenothiazine, showed M.A.O. inhibitory action and antidepressive action.
Until recently many psychotropic agents has been introduced and used widely in the field of psychiatry.
Author tried to find the influence of various psychotropic agents on gastric secretion and experimentally-induced peptic ulcer in rat. White male rat, average 180g of body weight was used as experimental animal.
Experiment on gastric secretion was carried out with the method of Shay(1945), With the centrifuged gastric secretory material, the P.H. was measured by Radiometer, Titrator TTT₂(Copenhagen), and gastric secretion amount was measured by Autoburett, ABU11 (Radiometer). Experiment of artificial gastric ulcer was carried out through the stress givent by ① pyloric ligation ② shaking ③ restraint with upside down position. Pathological change on the mucous membrane of rat stomach including hemorrhage, erosion and perforation etc. was observed by Stereoscope.
Result
(1) Diazepam inhibited gastric secretion (especially gastric acid) and lowered the acidity. Yet meprobamate on the contrary, raised gastric secretion and acidity, which might possibly be due to its peripheral effect.
(2) Chlorpromazine markedly depressed the gastric secretion. But Prochlorperazine, Haloperidol, and Reserpine did not show any significant change on gastric secretion, which might be due to their limited dosage to influence on gastric secretion.
(3) Tranylcypromine, and M.A.O. inhibitor, markedly reduced gastric secretion and gastric acidity. The Imipramine, tricyclic antidepressant with similar chemical structure of chlorpromazine, lowered the free acid of stomach in rat.
(4) The stress of pyloric ligation showed ulcerative change on rumen of stomach. Diazepam and Chlorpromazine premedicated rat did not reveal much change. But Tranylcypromine premedicated rat showed severe degree of ulcer change on all experimented rats and two of them were dead of perforation of stomach, which seemed to be the result of stomach, which seemed to be the result of stomach, which seemed to be the result of peripheral effect or decreased mucus of gastric secretion as an effect of relax action.
(5) The stress of shaking the rat brought erosion and edematous change on rumen but no ulcerative change took place. Diazepam premedicated group has not showed change on mucous membrane. Chlorpromazine premedicated group showed mild degree of change. But Reserpine treated group showed marked degree of ulcer change on the rumen and 4 of this group died of gastric perforation.
(6) The stress of restraint of rat with upside down position revealed marked degree of erosion and hemorrhage on glandular portion, but no change on rumen. But Diazepam, Chlorpromazine and Imipramine premedicated group of rats showed lesser degree above changes. As shown above, varions psychotropic agents influenced on gastric secretion and experimentally induced gastric ulcer in rats. It might be explained that most of the psychotropic agents could influence on biogenic amine metabolism of brain and on regulating anxiety, which prevent hypersecretion of stomach.
But as a few of the exception for instance. Tranylcypromine and Reserpine brought severe degree of ulcer change, which might possible be due to the peripheral effect.
Above two psychotropic agents are to be alarmed to use to the patient with peptic ulcer.
서지정보 내보내기(Export)
닫기소장기관 정보
닫기권호소장정보
닫기오류접수
닫기오류 접수 확인
닫기음성서비스 신청
닫기음성서비스 신청 확인
닫기이용약관
닫기학술연구정보서비스 이용약관 (2017년 1월 1일 ~ 현재 적용)
학술연구정보서비스(이하 RISS)는 정보주체의 자유와 권리 보호를 위해 「개인정보 보호법」 및 관계 법령이 정한 바를 준수하여, 적법하게 개인정보를 처리하고 안전하게 관리하고 있습니다. 이에 「개인정보 보호법」 제30조에 따라 정보주체에게 개인정보 처리에 관한 절차 및 기준을 안내하고, 이와 관련한 고충을 신속하고 원활하게 처리할 수 있도록 하기 위하여 다음과 같이 개인정보 처리방침을 수립·공개합니다.
주요 개인정보 처리 표시(라벨링)
목 차
3년
또는 회원탈퇴시까지5년
(「전자상거래 등에서의 소비자보호에 관한3년
(「전자상거래 등에서의 소비자보호에 관한2년
이상(개인정보보호위원회 : 개인정보의 안전성 확보조치 기준)개인정보파일의 명칭 | 운영근거 / 처리목적 | 개인정보파일에 기록되는 개인정보의 항목 | 보유기간 | |
---|---|---|---|---|
학술연구정보서비스 이용자 가입정보 파일 | 한국교육학술정보원법 | 필수 | ID, 비밀번호, 성명, 생년월일, 신분(직업구분), 이메일, 소속분야, 웹진메일 수신동의 여부 | 3년 또는 탈퇴시 |
선택 | 소속기관명, 소속도서관명, 학과/부서명, 학번/직원번호, 휴대전화, 주소 |
구분 | 담당자 | 연락처 |
---|---|---|
KERIS 개인정보 보호책임자 | 정보보호본부 김태우 | - 이메일 : lsy@keris.or.kr - 전화번호 : 053-714-0439 - 팩스번호 : 053-714-0195 |
KERIS 개인정보 보호담당자 | 개인정보보호부 이상엽 | |
RISS 개인정보 보호책임자 | 대학학술본부 장금연 | - 이메일 : giltizen@keris.or.kr - 전화번호 : 053-714-0149 - 팩스번호 : 053-714-0194 |
RISS 개인정보 보호담당자 | 학술진흥부 길원진 |
자동로그아웃 안내
닫기인증오류 안내
닫기귀하께서는 휴면계정 전환 후 1년동안 회원정보 수집 및 이용에 대한
재동의를 하지 않으신 관계로 개인정보가 삭제되었습니다.
(참조 : RISS 이용약관 및 개인정보처리방침)
신규회원으로 가입하여 이용 부탁 드리며, 추가 문의는 고객센터로 연락 바랍니다.
- 기존 아이디 재사용 불가
휴면계정 안내
RISS는 [표준개인정보 보호지침]에 따라 2년을 주기로 개인정보 수집·이용에 관하여 (재)동의를 받고 있으며, (재)동의를 하지 않을 경우, 휴면계정으로 전환됩니다.
(※ 휴면계정은 원문이용 및 복사/대출 서비스를 이용할 수 없습니다.)
휴면계정으로 전환된 후 1년간 회원정보 수집·이용에 대한 재동의를 하지 않을 경우, RISS에서 자동탈퇴 및 개인정보가 삭제처리 됩니다.
고객센터 1599-3122
ARS번호+1번(회원가입 및 정보수정)