디폴트 모드 연결망의 기억 부호화 및 공고화 신호 분석 = Memory Encoding and Consolidation in the Default Mode Networks

다국어 초록 (Multilingual Abstract)

The current study analyzed the neural signals from the default mode networks (DMN) using the subsequent memory paradigm and a resting-state functional connectivity (rsFC) analysis. Participants learned a number of scenes and faces during functional magnetic resonance imaging (fMRI) and later performed a recognition test. To define the DMN and track the changes in rsFC, resting-state scans were acquired before and after the learning phase. Based on subsequent recognition performance, trials in the learning phase were categorized into either subsequently remembered or subsequently forgotten trials. Here are two main findings: First, DMN subregions showed greater activation for subsequently forgotten than remembered trials. Such subsequent forgetting (SF) effects were most reliable in the right angular gyrus. Second, greater functional connectivity between the hippocampus and the parahippocampal place area (PPA) during the post-learning resting scan predicted better memory for the scenes in the subsequent recognition test. These findings provide information about memory encoding and consolidation functions in the DMN and support the necessity of network-level approaches to understand human memory.

국문 초록 (Abstract)

본 연구는 후속 기억 패러다임과 휴지기 기능적 연결성 분석을 통해 기억 생성에 관여하는 디폴트 모드 연결망의 신호를 분석하였다. 참가자들은 기능적 자기 공명 영상(functional magnetic resonance imaging, fMRI)을 촬영하는 동안 다수의 장면과 얼굴 사진들을 학습하였고 뇌 영상 촬영이 종료된 후에는 재인 검사를 수행하였다. 디폴트 모드 연결망(default mode networks, DMN)을 정의하고 휴지기 기능적 연결성의 변화를 추적하기 위해 학습 단계 전후에는 휴지기 영상을 촬영하였다. 재인 검사 결과를 바탕으로 학습 단계의 기능 영상을 사진이 기억된 시행과 망각된 시행으로 분류하여 비교하였다. 이를 통해 두 가지 주요 결과를 얻었다. 첫째, DMN의 하위 영역들은 나중에 기억된 자극보다 망각된 자극을 학습하는 동안 더 많이 활성화되었다. 특히 이러한 후속 망각(subsequent forgetting, SF) 효과는 우반구 각회(angular gyrus)에서 가장 두드러지게 나타났다. 둘째, 학습후 휴지기 영상에서 해마와 해마방 장소 영역의 기능적 연결성이 증가한 참가자일수록 후속 재인 검사에서 장면 사진을 더 정확하게 기억하였다. 본 연구는 디폴트 모드 연결망의 기억 부호화 및 공고화 기능을 하위 영역별로 상세하게 밝혔다. 이러한 결과는 기억의 생성 과정을 이해하기 위해 연결망 수준의 접근이 필요하다는 점을 시사한다.

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