사다리 운동이 시스플라틴으로 유도된 쥐의 골격근 내 미토콘드리아 기능에 미치는 영향 = The Effect of Ladder Exercise on Mitochondrial Function in Cisplatin-induced Rats Skeletal Muscle

다국어 초록 (Multilingual Abstract)

Purpose: The purpose of this study is to determine that the effect of ladder exercise for 8 weeks after cisplatin administration on mitochondrial O2 consumption and muscle morphology was analyzed. Methods: Total number of 23 rats were divided into Normal CON(n=6), Cisplatin CON(n=8), and Cisplatin+Ex(n=9). After 8 weeks of ladder exercise, we measured body weight, gastrocnemius(GAS) and soleus(SOL) muscle tissue weight. Also, the morphological cross-sectional muscle area, space area in each muscle, and number of myocyte cell. Each muscle was measured mitochondria O2 consumption after 8 weeks of ladder exercise. Result: These results showed Cisplatin+Ex group significantly improved each GAS and SOL muscle mass(p<.05), muscle cross-sectional area(p<.05), space area in muscle(p<.05), number of myocyte cells(p<.05). Also, the mitochondrial O2 consumption in GM(p<.05) and ADP(p<.05) was increased in Cisplatin+Ex group. Conclusion: Ladder exercise for 8 weeks after cisplatin administration indicated both SOL muscle increased muscle mass and improved morphological structure, and mitochondrial O2 consumption.

국문 초록 (Abstract)

연구목적: 본 연구에서는 Cisplatin 투여 후 8주간의 사다리 운동이 미토콘드리아 산소섭취량과 근육의 형태학적 구조에 미치는 영향을 파악하고자 한다. 연구방법: 총 23마리 중 Normal CON(n=6), Cisplatin CON(n=8), Cisplatin+Ex(n=9)으로 나누어 8주간의 저항성 운동 후 몸무게, gastrocnemius(GAS)와 soleus(SOL) 근육 조직 무게를 측정하였다. 또한 근육의 단면적, 근육 내 빈공간, 근세포 숫자를 측정하였고, 각 조직별 미토콘드리아 산소섭취량을 측정하였다. 결과: Cisplatin 투여 후 8주간의 저항성 운동이 투여 후 운동을 하지 않은 그룹(Cisplatin CON)보다 근육 조직의 근육 무게의 증가(p<.05) 및 근육의 단면적(p<.05), 근육 내 빈공간(p<.05) 그리고 근세포 숫자(p<.05)의 증가가 나타났다. 특히 Cisplatin+Ex 그룹에서 GAS와 SOL 근육에서 미토콘드리아 기능인 GM과 ADP의 산소섭취량이 Cisplatin CON보다 높게 나타났다. 결론: Cisplatin을 투여 후 8주간의 저항성 운동은 SOL 근육 조직 무게 증가 및 형태학적 구조를 개선하는 것으로 나타냈고, 근육의 미토콘드리아 산소섭취량은 운동을 통해 증가되는 것으로 확인되었다.

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