Bioactive peptides-derived from marine by-products: development, health benefits and potential application in biomedicine

다국어 초록 (Multilingual Abstract)

Increased fisheries products have raised by-products that are discarded due to low economic value. In addition, marine by-products are still rich in protein and nutritional value that have biological activities and give benefits to human health. Meanwhile, there is raised pressure for sustainability practices in marine industries to reduce waste and minimize the detrimental effect on the environment. Thus, valorization by-products through bioactive peptide mining are crucial. This review focus on various ways to obtain bioactive peptides from marine by-products through protein hydrolysis, for instance chemical hydrolysis (acid and based), biochemical hydrolysis (autolysis and enzymatic hydrolysis), microbial fermentation, and subcritical water hydrolysis.
Nevertheless, these processes have benefits and drawbacks which need to be considered. This review also addresses various biological activities that are favorable in pharmaceutical industries, including antioxidant, antihypertensive, anticancer, anti-obesity, and other beneficial bioactivities. In addition, some potential marine resources of Indonesia for the marine biopeptide from their by-product or undesired marine commodities would be addressed as well.

참고문헌 (Reference)

• 1 감민주 ; 엄미향 ; 계승희, "노인의 건강기능식품 섭취 실태와 영양지수를 이용한 식사의 질 및 영양 평가" 한국식생활문화학회 34 (34): 474-485, 2019
• 2 Rajendran SRCK, "Yield, physicochemical, and antioxidant properties of Atlantic salmon visceral hydrolysate : comparison of lactic acid bacterial fermentation with flavourzyme proteolysis and formic acid treatment" 42 : e13620-, 2018
• 3 Jang HJ, "Wound-healing effects of human dermal components with gelatin dressing" 32 : 716-724, 2018
• 4 World Health Organization, "World health statistics 2020: monitoring health for the SDGs, sustainable development goals" World Health Organization 77-, 2020
• 5 Varona S, "Vascular lysyl oxidase over-expression alters extracellular matrix structure and induces oxidative stress" 29 : 157-165, 2017
• 6 Saidi S, "Valorisation of tuna processing waste biomass : isolation, purification and characterisation of four novel antioxidant peptides from tuna by-product hydrolysate" 25 : 17383-17392, 2018
• 7 Vázquez JA, "Valorisation of fish discards assisted by enzymatic hydrolysis and microbial bioconversion : lab and pilot plant studies and preliminary sustainability evaluation" 246 : 119027-, 2020
• 8 de Jesus JHF, "Thermal behavior and polymorphism of the antioxidants : BHA, BHT and TBHQ" 278 : 118298-, 2020
• 9 Gálico DA, "Thermal and spectroscopic studies of the antioxidant food additive propyl gallate" 182 : 89-94, 2015
• 10 Food and Agriculture Organization of the United Nations, "The state of world fisheries and aquaculture 2020: sustainability in action" FAO 2020
• 11 Stevens JR, "The rise of aquaculture by-products : increasing food production, value, and sustainability through strategic utilisation" 90 : 115-124, 2018
• 12 Vijayan A, "The relationship of lipid peroxidation and antioxidant status to selected modifiable risk factors in coronary artery disease patients" 8 : 100077-, 2021
• 13 Chen J, "The molecular mechanisms of copper metabolism and its roles in human diseases" 472 : 1415-1429, 2020
• 14 Lu H, "The inhibition of reactive oxygen species(ROS)by antioxidants inhibits the release of an autophagy marker in ectopic endometrial cells" 59 : 256-261, 2020
• 15 Chooi YC, "The epidemiology of obesity" 92 : 6-10, 2019
• 16 Lima DAS, "Technological properties of protein hydrolysate from the cutting byproduct of serra spanish mackerel(Scomberomorus brasiliensis)" 58 : 2952-2962, 2021
• 17 Xu X, "Synthetic phenolic antioxidants: metabolism, hazards and mechanism of action" 129488-, 2021
• 18 Melgosa R, "Supercritical CO2 and subcritical water technologies for the production of bioactive extracts from sardine(Sardina pilchardus)waste" 164 : 104943-, 2020
• 19 Ahmed R, "Subcritical water hydrolysis for the production of bioactive peptides from tuna skin collagen" 141 : 88-96, 2018
• 20 Wang LL, "Study on the effect of reactive oxygen species-mediated oxidative stress on the activation of mitochondrial apoptosis and the tenderness of yak meat" 244 : 394-402, 2018
• 21 Kumari R, "Structure-based mimicking of hydroxylated biphenyl congeners(OHPCBs)for human transthyretin, an important enzyme of thyroid hormone system" 105 : 107870-, 2021
• 22 Zhang X, "Structural characteristics and stability of salmon skin protein hydrolysates obtained with different proteases" 153 : 112460-, 2022
• 23 Versteegden LR, "Self-expandable tubular collagen implants" 12 : 1494-1498, 2018
• 24 Irianto HE, "Seafood processing by-products" Springer 21-34, 2014
• 25 Kliche T, "Screening for proteolytically active lactic acid bacteria and bioactivity of peptide hydrolysates obtained with selected strains" 101 : 7621-7633, 2017
• 26 Jiang W, "Recovery of proteins from squid by-products with enzymatic hydrolysis and increasing the hydrolysate’s bioactivity by Maillard reaction" 27 : 900-911, 2018
• 27 Guo N, "Recovery of chitin and protein from shrimp head waste by endogenous enzyme autolysis and fermentation" 18 : 719-726, 2019
• 28 Wang CH, "Reclamation of fishery processing waste : a mini-review" 24 : 2234-, 2019
• 29 Hsu KC, "Purification of antioxidative peptides prepared from enzymatic hydrolysates of tuna dark muscle by-product" 122 : 42-48, 2010
• 30 Bougatef A, "Purification and identification of novel antioxidant peptides from enzymatic hydrolysates of sardinelle(Sardinella aurita)by-products proteins" 118 : 559-565, 2010
• 31 Wang K, "Purification and identification of anti-allergic peptide from Atlantic salmon(Salmo salar)byproduct enzymatic hydrolysates" 72 : 104084-, 2020
• 32 Zhang K, "Purification and characterization of a novel calcium-binding decapeptide from Pacific cod(Gadus Macrocephalus)bone : molecular properties and calcium chelating modes" 52 : 670-679, 2019
• 33 Lian D, "Puerarin inhibits hyperglycemia-induced inter-endothelial junction through suppressing endothelial Nlrp3 inflammasome activation via ROS-dependent oxidative pathway" 55 : 310-319, 2019
• 34 Foegeding EA, "Protein-polyphenol particles for delivering structural and health functionality" 72 : 163-173, 2017
• 35 Vieira EF, "Protein hydrolysate from canned sardine and brewing by-products improves TNF-α-induced inflammation in an intestinal-endothelial co-culture cell model" 57 : 2275-2286, 2018
• 36 Priatni S, "Protein and fatty acid profile of marine fishes from Java Sea, Indonesia" 19 : 1737-1742, 2018
• 37 Salmanzadeh R, "Propyl gallate(PG)and tert-butylhydroquinone(TBHQ)may alter the potential anti-cancer behavior of probiotics" 24 : 37-45, 2018
• 38 Kook YM, "Promotion of vascular morphogenesis of endothelial cells co-cultured with human adipose-derived mesenchymal stem cells using polycaprolactone/gelatin nanofibrous scaffolds" 8 : 117-, 2018
• 39 Jackson A, "Project to model the use of fisheries by-products in the production of marine ingredients with special reference to omega-3 fatty acids EPA and DHA"
• 40 Mongkonkamthorn N, "Production of protein hydrolysate containing antioxidant and angiotensin-I-converting enzyme(ACE)inhibitory activities from tuna(Katsuwonus pelamis)blood" 8 : 1518-, 2020
• 41 Petrova I, "Production of fish protein hydrolysates step by step : technological aspects, equipment used, major energy costs and methods of their minimizing" 10 : 223-241, 2018
• 42 Prihanto AA, "Production and characteristics of fish protein hydrolysate from parrotfish(Chlorurus sordidus)head" 7 : e8297-, 2019
• 43 Link W, "Principles of cancer treatment and anticancer drug development" Springer 2019
• 44 Shen K, "Preparation of protein powder from the liver of yellowfin tuna (Thunnus albacores): a comparison of acid- and alkali-aided pH-shifting" 42 : 2021
• 45 Yang XR, "Preparation and characterization of gelatin and antioxidant peptides from gelatin hydrolysate of skipjack tuna(Katsuwonus pelamis)bone stimulated by in vitro gastrointestinal digestion" 17 : 78-, 2019
• 46 Walters ME, "Potential of food hydrolyzed proteins and peptides to chelate iron or calcium and enhance their absorption" 7 : 172-, 2018
• 47 Chen M, "Polyhedral oligomeric silsesquioxane-incorporated gelatin hydrogel promotes angiogenesis during vascularized bone regeneration" 12 : 22410-22425, 2020
• 48 Choi JS, "Physiological properties of Engraulis japonicus muscle protein hydrolysates prepared by subcritical water hydrolysis" 38 : 283-289, 2017
• 49 Abdollahi M, "Physicochemical and gel-forming properties of protein isolated from salmon, cod and herring by-products using the pH-shift method" 101 : 678-684, 2019
• 50 Zamora-Sillero J, "Peptides from fish by-product protein hydrolysates and its functional properties : an overview" 20 : 118-130, 2018
• 51 Hajfathalian M, "Peptides : production, bioactivity, functionality, and applications" 58 : 3097-3129, 2018
• 52 Pisoschi AM, "Oxidative stress mitigation by antioxidants : an overview on their chemistry and influences on health status" 209 : 112891-, 2021
• 53 Bui XD, "Optimization of production parameters of fish protein hydrolysate from Sarda Orientalis black muscle(by-product)using protease enzyme" 23 : 31-40, 2021
• 54 Mirzapour-Kouhdasht A, "Optimization of gelatin production from barred mackerel by-products : characterization and hydrolysis using native and commercial proteases" 108 : 105970-, 2020
• 55 Álvarez C, "Optimised protein recovery from mackerel whole fish by using sequential acid/alkaline isoelectric solubilization precipitation(ISP)extraction assisted by ultrasound" 88 : 210-216, 2018
• 56 Blüher M, "Obesity : global epidemiology and pathogenesis" 15 : 288-298, 2019
• 57 Kang NJ, "New approaches towards the discovery and evaluation of bioactive peptides from natural resources" 50 : 72-103, 2020
• 58 Kang MG, "Nanogels derived from fish gelatin : application to drug delivery system" 17 : 246-, 2019
• 59 Trilaksani W, "Nano collagen of the grouper swim bladder in compliance with quality standard of cosmetics materials" 404 : 012050-, 2020
• 60 Knopf-Marques H, "Multifunctional polymeric implant coatings based on gelatin, hyaluronic acid derivative and chain length-controlled poly(arginine)" 104 : 109898-, 2019
• 61 Mancini S, "Modifications of fatty acids profile, lipid peroxidation and antioxidant capacity in raw and cooked rabbit burgers added with ginger" 133 : 151-158, 2017
• 62 Siddeeg A, "Mode of action and determination of antioxidant activity in the dietary sources : an overview" 28 : 1633-1644, 2021
• 63 Vujic A, "Mitochondrial redox and TCA cycle metabolite signaling in the heart" 166 : 287-296, 2021
• 64 Cortassa S, "Mitochondrial Ca2+, redox environment and ROS emission in heart failure : two sides of the same coin?" 151 : 113-125, 2021
• 65 Neha K, "Medicinal prospects of antioxidants : a review" 178 : 687-704, 2019
• 66 Pujiastuti DY, "Marine organisms as potential sources of bioactive peptides that inhibit the activity of angiotensin I-converting enzyme : a review" 24 : 2541-, 2019
• 67 Fawzya YN, "Marine niche: applications in pharmaceutical sciences" Springer Singapore 283-297, 2020
• 68 Venkatesan J, "Marine fish proteins and peptides for cosmeceuticals : a review" 15 : 143-, 2017
• 69 Costello MJ, "Marine biodiversity, biogeography, deep-sea gradients, and conservation" 27 : R511-27, 2017
• 70 Chasanah E, "Marine biodiscovery research in Indonesia : challenges and rewards" 12 : 1-12, 2008
• 71 Jo C, "Marine bioactive peptides : types, structures, and physiological functions" 33 : 44-61, 2017
• 72 Nigam M, "Marine anticancer drugs and their relevant targets : a treasure from the ocean" 27 : 491-515, 2019
• 73 Ministry of Marine Affairs and Fisheries, "Marine and fishery production"
• 74 Peña-Bautista C, "Lipid peroxidation biomarkers correlation with medial temporal atrophy in early Alzheimer Disease" 129 : 104519-, 2019
• 75 Wang YJ, "Lipid oxidation induced oxidative degradation of cereal beta-glucan" 197 : 1324-1330, 2016
• 76 Sasaki C, "Isolation and identification of an angiotensin I-converting enzyme inhibitory peptide from pearl oyster(Pinctada fucata)shell protein hydrolysate" 77 : 137-142, 2019
• 77 Joshi I, "Isolation and characterization of angiotensin I-converting enzyme(ACE-I)inhibition and antioxidant peptide from by-catch shrimp(Oratosquilla woodmasoni)waste" 29 : 101770-, 2020
• 78 Hutomo M, "Indonesian marine and coastal biodiversity : present status" 34 : 88-97, 2005
• 79 Daroit DJ, "In vivo bioactivities of food protein-derived peptides : a current review" 39 : 120-129, 2021
• 80 Song R, "In vitro antioxidative activities of squid(Ommastrephes bartrami)viscera autolysates and identification of active peptides" 51 : 1674-1682, 2016
• 81 Zhou DY, "In vitro antioxidant activity of enzymatic hydrolysates prepared from abalone(Haliotis discus hannai Ino)viscera" 90 : 148-154, 2012
• 82 Karthik R, "In vitro and in vivo anticancer activity of posterior salivary gland toxin from the cuttlefish Sepia pharaonis, Ehrenberg(1831)" 272 : 10-20, 2017
• 83 Song Y, "In situ formation of injectable chitosan-gelatin hydrogels through double crosslinking for sustained intraocular drug delivery" 88 : 1-12, 2018
• 84 Martí-Quijal FJ, "Impact of fermentation on the recovery of antioxidant bioactive compounds from sea bass byproducts" 9 : 239-, 2020
• 85 Mora Román JJ, "Immunotherapeutic potential of mollusk hemocyanins in combination with human vaccine adjuvants in murine models of oral cancer" 2019 : 7076942-, 2019
• 86 Yu F, "Immunomodulatory activity of low molecular-weight peptides from Nibea japonica skin in cyclophosphamide-induced immunosuppressed mice" 68 : 103888-, 2020
• 87 Wu W, "Identification of iron-chelating peptides from Pacific cod skin gelatin and the possible binding mode" 35 : 418-427, 2017
• 88 Alemán A, "Identification of ace-inhibitory peptides from squid skin collagen after in vitro gastrointestinal digestion" 54 : 790-795, 2013
• 89 Ye Q, "Identification and assessment of residual levels of the main oxidation product of tert-butylhydroquinone in frying oils after heating and its cytotoxicity to RAW 264. 7 cells" 264 : 293-300, 2018
• 90 Zhang L, "Identification and active evaluation of antioxidant peptides from protein hydrolysates of skipjack tuna(Katsuwonus pelamis)head" 8 : 318-, 2019
• 91 Affane F, "Hypolipidemic, antioxidant and antiatherogenic property of sardine by-products proteins in highfat diet induced obese rats" 199 : 16-22, 2018
• 92 Te Riet L, "Hypertension : renin-angiotensin-aldosterone system alterations" 116 : 960-975, 2015
• 93 Yuswan MH, "Hydroxyproline determination for initial detection of halal-critical food ingredients(gelatin and collagen)" 337 : 127762-, 2021
• 94 Nikoo M, "Hydrolysates from rainbow trout(Oncorhynchus mykiss)processing by-products : properties when added to fish mince with different freeze-thaw cycles" 30 : 100418-, 2019
• 95 Han Y, "High-precision, gelatin-based, hybrid, bilayer scaffolds using melt electro-writing to repair cartilage injury" 6 : 2173-2186, 2021
• 96 Pal S, "High glucose-induced ROS accumulation is a critical regulator of ERK1/2-Akt-tuberin-mTOR signalling in RGC-5 cells" 256 : 117914-, 2020
• 97 Atef M, "Health benefits and food applications of bioactive compounds from fish byproducts : a review" 35 : 673-681, 2017
• 98 World Health Organization, "Global recommendations on physical activity for health" World Health Organization 2010
• 99 Zeller D, "Global marine fisheries discards : a synthesis of reconstructed data" 19 : 30-39, 2018
• 100 Ucak I, "Functional and bioactive properties of peptides derived from marine side streams" 19 : 71-, 2021
• 101 Ngo DH, "Free radical scavenging and angiotensin-I converting enzyme inhibitory peptides from Pacific cod(Gadus macrocephalus)skin gelatin" 49 : 1110-1116, 2011
• 102 Li W, "Free radical scavenging activity of type II collagen peptides and chondroitin sulfate oligosaccharides from by-products of mottled skate processing" 41 : 100991-, 2021
• 103 Pezeshk S, "Fractionation of protein hydrolysates of fish waste using membrane ultrafiltration : investigation of antibacterial and antioxidant activities" 11 : 1015-1022, 2019
• 104 Chakrabarti S, "Food-derived bioactive peptides in human health : challenges and opportunities" 10 : 1738-, 2018
• 105 Ashraf SA, "Fish-based bioactives as potent nutraceuticals : exploring the therapeutic perspective of sustainable food from the sea" 18 : 265-, 2020
• 106 Coppola D, "Fish waste : from problem to valuable resource" 19 : 116-, 2021
• 107 Villamil O, "Fish viscera protein hydrolysates : production, potential applications and functional and bioactive properties" 224 : 160-171, 2017
• 108 Lee EJ, "Fish collagen peptide inhibits the adipogenic differentiation of preadipocytes and ameliorates obesity in high fat diet-fed mice" 104 : 281-286, 2017
• 109 Heo SY, "Fish bone peptide promotes osteogenic differentiation of MC3T3-E1 pre-osteoblasts through upregulation of MAPKs and Smad pathways activated BMP-2 receptor" 36 : 137-146, 2018
• 110 Sghayyar HNM, "Fish biowaste gelatin coated phosphate-glass fibres for wound-healing application" 122 : 109386-, 2020
• 111 Ghorbel-Bellaaj O, "Fermented shrimp waste hydrolysates : promising source of functional molecules with antioxidant properties" 16 : 357-377, 2018
• 112 Hajeb P, "Fermented shrimp products as source of umami in Southeast Asia" S10 : 006-, 2012
• 113 Marti-Quijal FJ, "Fermentation in fish and by-products processing : an overview of current research and future prospects" 31 : 9-16, 2020
• 114 Radhika Rajasree SR, "Fabrication and characterization of chitosan based collagen/gelatin composite scaffolds from big eye snapper Priacanthus hamrur skin for antimicrobial and anti oxidant applications" 107 : 110270-, 2020
• 115 Ab Rahman WNS, "Extraction of local fish waste by subcritical water" 15 : 716-719, 2019
• 116 Luan X, "Excessive reactive oxygen species induce apoptosis via the APPL1-Nrf2/HO-1 antioxidant signalling pathway in trophoblasts with missed abortion" 254 : 117781-, 2020
• 117 Beaulieu L, "Evidence of anti-proliferative activities in blue mussel(Mytilus edulis)by-products" 11 : 975-990, 2013
• 118 Sellimi S, "Enhancing colour and oxidative stabilities of reduced-nitrite turkey meat sausages during refrigerated storage using fucoxanthin purified from the Tunisian seaweed Cystoseira barbata" 107 : 620-629, 2017
• 119 Liu C, "Enhanced osteoinductivity and corrosion resistance of dopamine/gelatin/rhBMP-2–coated β-TCP/Mg-Zn orthopedic implants : an in vitro and in vivo study" 15 : e0228247-, 2020
• 120 Siahaan EA, "Encyclopedia Mar Biotechnol" 3213-3227, 2020
• 121 Nghia ND, "Encyclopedia Mar Biotechnol" 2961-2986, 2020
• 122 de Silva MPKSK, "Efficiency of biotransformation of shellfish waste to carotenoprotein by autolysis and crab-shrimp endo-enzymes" 30 : 526-534, 2021
• 123 Wang Z, "Effects of malondialdehyde as a byproduct of lipid oxidation on protein oxidation in rabbit meat" 288 : 405-412, 2019
• 124 Rahman MS, "Effects of elevated temperature on prooxidant-antioxidant homeostasis and redox status in the American oyster : signaling pathways of cellular apoptosis during heat stress" 196 : 110428-, 2021
• 125 Feki A, "Effect of the incorporation of polysaccharide from Falkenbergia rufolanosa on beef sausages for quality and shelf life improvement" 143 : 111139-, 2021
• 126 Zhou Y, "Effect of the flavonoid baicalein as a feed additive on the growth performance, immunity, and antioxidant capacity of broiler chickens" 98 : 2790-2799, 2019
• 127 Hao G, "Effect of temperature on chemical properties and antioxidant activities of abalone viscera subcritical water extract" 147 : 17-23, 2019
• 128 Karimi N, "Effect of pacific white shrimp(Litopenaeus vannamei)protein hydrolysates(SPH)and(-)-epigallocatechin gallate(EGCG)on sourdough and bread quality" 131 : 109800-, 2020
• 129 Setijawati D, "Effect of incubation time and pH on the protein characterization of the aqueous soluble phase of acidified mackerel by-product" 493 : 012030-, 2020
• 130 He Y, "Effect of blood pressure on early neurological deterioration of acute ischemic stroke patients with intravenous rt-PA thrombolysis may be mediated through oxidative stress induced blood-brain barrier disruption and AQP4 upregulation" 29 : 104997-, 2020
• 131 Carmona-Maurici J, "Effect of bariatric surgery in the evolution of oxidative stress depending on the presence of atheroma in patients with morbid obesity" 16 : 1258-1265, 2020
• 132 Lee JK, "Effect of angiotensin I converting enzyme inhibitory peptide purified from skate skin hydrolysate" 125 : 495-499, 2011
• 133 Putra MY, "Distribution and diversity of marine natural products from Indonesian marine organisms" 4 : 104-107, 2016
• 134 Maeda H, "Dietary tuna dark muscle protein attenuates hepatic steatosis and increases serum high-density lipoprotein cholesterol in obese type-2 diabetic/obese KK-Ay mice" 82 : 1231-1238, 2017
• 135 Luo J, "Diet-derived circulating antioxidants and risk of coronary heart disease : a Mendelian randomization study" 77 : 45-54, 2021
• 136 Azaza YB, "Development and characterization of active packaging films based on chitosan and sardinella protein isolate : effects on the quality and the shelf life of shrimps" 31 : 100796-, 2022
• 137 Asaad I, "Delineating priority areas for marine biodiversity conservation in the Coral Triangle" 222 : 198-211, 2018
• 138 Michurina S, "Decreased UCP-1 expression in beige adipocytes from adipose-derived stem cells of type 2 diabetes patients associates with mitochondrial ROS accumulation during obesity" 169 : 108410-, 2020
• 139 Vo TDL, "Copper-chelating peptide from salmon by-product proteolysate" 16 : 2020
• 140 Papaccio F, "Concise review : cancer cells, cancer stem cells, and mesenchymal stem cells : influence in cancer development" 6 : 2115-2125, 2017
• 141 da Cruz RG, "Comparison of the antioxidant property of acerola extracts with synthetic antioxidants using an in vivo method with yeasts" 277 : 698-705, 2019
• 142 Nisov A, "Comparison of enzymatic and pH shift methods to extract protein from whole Baltic herring(Clupea harengus membras)and roach(Rutilus rutilus)" 373 : 131524-, 2022
• 143 Lapeña D, "Comparative assessment of enzymatic hydrolysis for valorization of different protein-rich industrial byproducts" 66 : 9738-9749, 2018
• 144 Ben Slimane E, "Collagen from cartilaginous fish by-products for a potential application in bioactive film composite" 16 : 211-, 2018
• 145 Kongkaoroptham P, "Chitosan nanoparticles based on their derivatives as antioxidant and antibacterial additives for active bioplastic packaging" 257 : 117610-, 2021
• 146 Thenu JL, "Chemical compositions and amino acids of dolphin fish(Coryphaena hippurus)roes" 2017
• 147 Devita L, "Chemical and antioxidant characteristics of skin-derived collagen obtained by acid-enzymatic hydrolysis of bigeye tuna(Thunnus obesus)" 19 : 222-, 2021
• 148 Wang X, "Characterization, preparation, and purification of marine bioactive peptides" 2017 : 9746720-, 2017
• 149 Nurilmala M, "Characterization of collagen and its hydrolysate from yellowfin tuna Thunnus albacares skin and their potencies as antioxidant and antiglycation agents" 85 : 591-599, 2019
• 150 Nurilmala M, "Characterization and antioxidant activity of collagen, gelatin, and the derived peptides from yellowfin tuna(Thunnus albacares)skin" 18 : 98-, 2020
• 151 Nugroho G, "Characteristics of tuna viscera(Thunnus sp. )hydrolysate protein fermented by Bacillus licheniformis" 7 : 101-107, 2020
• 152 Jaziri AA, "Characteristics of peptones from grouper(Epinephelus fuscoguttatus)and parrotfish(Scarus javanicus)head by-products as bacterial culture media" 11 : 1-12, 2020
• 153 Setijawati D, "Characteristics of peptone from the mackerel, Scomber japonicus head by-product as bacterial growth media" 12 : 829-836, 2019
• 154 Nurdiani R, "Characteristics of fish protein hydrolysate from mackerel (Scomber japonicus) by-products" 49 : 2022
• 155 Fadilah N, "Characteristic of blue swim crab mustard (Portunus pelagicus) protein hydrolysate with different papain enzyme concentrations" 17 : 2020
• 156 Wellenstein MD, "Cancer-cell-intrinsic mechanisms shaping the tumor immune landscape" 48 : 399-416, 2018
• 157 Kumar D, "Cancer cell metabolism : a potential target for cancer therapy" Springer Singapore 2020
• 158 Miller ME, "Cancer" Momentum Press 2018
• 159 Gao J, "Bone marrow mesenchymal stem cells improve bone erosion in collagen-induced arthritis by inhibiting osteoclasia-related factors and differentiating into chondrocytes" 11 : 171-, 2020
• 160 da Silva CP, "Biological value of shrimp protein hydrolysate by-product produced by autolysis" 80 : 456-461, 2017
• 161 Zamorano-Apodaca JC, "Biological and functional properties of peptide fractions obtained from collagen hydrolysate derived from mixed by-products of different fish species" 331 : 127350-, 2020
• 162 Camargo TR, "Biological activities of the protein hydrolysate obtained from two fishes common in the fisheries bycatch" 342 : 128361-, 2021
• 163 Lima KO, "Bioactivity and bioaccessibility of protein hydrolyzates from industrial byproducts of stripped weakfish(Cynoscion guatucupa)" 111 : 408-413, 2019
• 164 Nurdiani R, "Bioactive peptides with radical scavenging and cancer cell cytotoxic activities derived from flathead(Platycephalus fuscus)by-products" 243 : 627-637, 2017
• 165 Hayes M, "Bioactive peptides from marine processing byproducts" 57-71, 2013
• 166 Pangestuti R, "Bioactive peptide of marine origin for the prevention and treatment of non-communicable diseases" 15 : 67-, 2017
• 167 Karami Z, "Bioactive food derived peptides : a review on correlation between structure of bioactive peptides and their functional properties" 56 : 535-547, 2019
• 168 Patra S, "Bioactive compounds from marine invertebrates as potent anticancer drugs : the possible pharmacophores modulating cell death pathways" 47 : 7209-7228, 2020
• 169 Hernández-Zazueta MS, "Bioactive compounds from Octopus vulgaris ink extracts exerted anti-proliferative and anti-inflammatory effects in vitro" 151 : 112119-, 2021
• 170 Abdelhedi O, "Basic and recent advances in marine antihypertensive peptides : production, structure-activity relationship and bioavailability" 88 : 543-557, 2019
• 171 Dave D, "Availability of marine collagen from Newfoundland fisheries and aquaculture waste resources" 7 : 100271-, 2019
• 172 Nikoo M, "Autolysis of rainbow trout(Oncorhynchus mykiss)by-products : enzymatic activities, lipid and protein oxidation, and antioxidant activity of protein hydrolysates" 140 : 110702-, 2021
• 173 Nikoo M, "Autolysis of Pacific white shrimp(Litopenaeus vannamei)processing by-products : enzymatic activities, lipid and protein oxidation, and antioxidant activity of hydrolysates" 39 : 100844-, 2021
• 174 Valencia P, "Assessing the enzymatic hydrolysis of salmon frame proteins through different by-product/water ratios and pH regimes" 10 : 3045-, 2021
• 175 Al Khawli F, "Aquaculture and its by-products as a source of nutrients and bioactive compounds" 92 : 1-33, 2020
• 176 Lu WY, "Application of marine natural products in drug research" 35 : 116058-, 2021
• 177 He D, "Antitumor bioactivity of porphyran extracted from Pyropia yezoensis Chonsoo2 on human cancer cell lines" 99 : 6722-6730, 2019
• 178 Taira Y, "Antioxidative effects of a novel dietary supplement Neumentix in a mouse stroke model" 29 : 104818-, 2020
• 179 Shavandi A, "Antioxidant and functional properties of protein hydrolysates obtained from squid pen chitosan extraction effluent" 227 : 194-201, 2017
• 180 Djellouli M, "Antioxidant and antimicrobial enhancement by reaction of protein hydrolysates derived from shrimp by-products with glucosamine" 11 : 2491-2505, 2020
• 181 Kusumaningtyas E, "Antioxidant and antifungal activities of collagen hydrolysates from skin of milkfish(Chanos chanos)hydrolyzed using various bacillus proteases" 278 : 012040-, 2019
• 182 Qian ZJ, "Antioxidant and angiotensin I converting enzyme inhibition effects and antihypertensive effect in spontaneously hyertensive rats of peptide isolated from boiled abalone by-products, Hallotis discus hannai" 27 : 946-960, 2018
• 183 Yaghoubzadeh Z, "Antioxidant activity and anticancer effect of bioactive peptides from rainbow trout(Oncorhynchus mykiss)skin hydrolysate" 26 : 625-632, 2020
• 184 Kang HK, "Antimicrobial and immunomodulatory properties and applications of marine-derived proteins and peptides" 17 : 350-, 2019
• 185 Abachi S, "Antihypertensive and angiotensin-I-converting enzyme(ACE)-inhibitory peptides from fish as potential cardioprotective compounds" 17 : 613-, 2019
• 186 Raja K, "Anti-proliferative and apoptotic effects of by-product(skin extract)from marine catfish Tachysurus dussumieri" 29 : 101816-, 2020
• 187 Woo M, "Anti-obesity effects of collagen peptide derived from skate(Raja kenojei)skin through regulation of lipid metabolism" 16 : 306-, 2018
• 188 Lin L, "Angiotensin-I-converting enzyme(ACE)-inhibitory and antihypertensive properties of squid skin gelatin hydrolysates" 131 : 225-230, 2012
• 189 Shrivastava A, "An assessment of serum oxidative stress and antioxidant parameters in patients undergoing treatment for cervical cancer" 167 : 29-35, 2021
• 190 Lee HJ, "Amino acid profiles and biopotentiality of hydrolysates obtained from comb penshell(Atrina pectinata)viscera using subcritical water hydrolysis" 19 : 137-, 2021
• 191 Abhari K, "Alternative extraction techniques to obtain, isolate and purify proteins and bioactive from aquaculture and by-products" 92 : 35-52, 2020
• 192 Ziegler SJ, "Advances in integrative structural biology: towards understanding protein complexes in their cellular context" 19 : 214-225, 2020
• 193 Wibawa SF, "Acid soluble collagen from skin of common carp (Cyprinus carpio L), red snapper (Lutjanus sp.) and milkfish (Chanos chanos)" 33 : 990-995, 2015
• 194 Surasani VKR, "Acid and alkaline solubilization(pH shift)process : a better approach for the utilization of fish processing waste and by-products" 25 : 18345-18363, 2018
• 195 Zahra K, "A study of oxidative stress in cervical cancer-an institutional study" 25 : 100881-, 2020
• 196 Wei LG, "A gelatin/collagen/polycaprolactone scaffold for skin regeneration" 7 : e6358-, 2019
• 197 Wang Z, "A comprehensive insight into the effects of microbial spoilage, myoglobin autoxidation, lipid oxidation, and protein oxidation on the discoloration of rabbit meat during retail display" 172 : 108359-, 2021
• 198 Caleja C, "A comparative study between natural and synthetic antioxidants : evaluation of their performance after incorporation into biscuits" 216 : 342-346, 2017
• 199 Mechri S, "A biological clean processing approach for the valorization of speckled shrimp Metapenaeus monoceros by-product as a source of bioactive compounds" 27 : 15842-15855, 2020
• 200 Choy BC, "A 10-year meta-analysis of membrane protein structural biology : detergents, membrane mimetics, and structure determination techniques" 1863 : 183533-, 2021